{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T05:45:50Z","timestamp":1782625550221,"version":"3.54.5"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,1,11]],"date-time":"2017-01-11T00:00:00Z","timestamp":1484092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"none reported"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Some wheezing toddlers develop asthma later in childhood. Sensitization is known to predict asthma in birth cohorts. However, its predictive value in secondary healthcare is uncertain. Aim: This study examines the predictive value of sensitization to inhalant allergens among wheezing toddlers in secondary healthcare for the development of asthma at school age (\u22656 years). Methods: Preschool children (1\u20133 years) who presented with wheezing in secondary healthcare were screened on asthma at school age with the International Study of Asthma and Allergies in Childhood questionnaire. The positive and negative predictive value (PPV and NPV) of specific IgE to inhalant allergens (cut\u2010off concentration 0.35\u2009kU\/L) and several non\u2010invasive variables from a child's history (such as hospitalization, eczema, and parental atopy) were calculated. The additional predictive value of sensitization when combined with non\u2010invasive predictors was examined in multivariate analysis and by ROC curves. Results: Of 116 included children, 63% developed asthma at school age. Sensitization to inhalant allergens was a strong asthma predictor. The odds ratio (OR), PPV and NPV were 7.4%, 86%, and 55%, respectively. Eczema (OR 3.4) and hospital admission (OR 2.6) were significant non\u2010invasive determinants. Adding sensitization to these non\u2010invasive predictors in multivariate analysis resulted in a significantly better asthma prediction. The area under the ROC curve increased from 0.70 with only non\u2010invasive predictors to 0.79 after adding sensitization. Conclusion: Sensitization to inhalant allergens is a strong predictor of school age asthma in secondary healthcare and has added predictive value when combined with non\u2010invasive determinants. <jats:bold>Pediatr Pulmonol. 2017;52:729\u2013736.<\/jats:bold> \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.23668","type":"journal-article","created":{"date-parts":[[2017,1,11]],"date-time":"2017-01-11T17:42:51Z","timestamp":1484156571000},"page":"729-736","source":"Crossref","is-referenced-by-count":15,"title":["Sensitization predicts asthma development among wheezing toddlers in secondary healthcare"],"prefix":"10.1002","volume":"52","author":[{"given":"Nienke A.","family":"Boersma","sequence":"first","affiliation":[{"name":"Department of Pediatrics St. Antonius Hospital PO Box 2500 3430 EM Nieuwegein The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruud W.H.","family":"Meijneke","sequence":"additional","affiliation":[{"name":"Department of Pediatrics St. Antonius Hospital PO Box 2500 3430 EM Nieuwegein The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes C.","family":"Kelder","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences and Education St. Antonius Hospital Nieuwegein The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelis K.","family":"van der Ent","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter A.F.","family":"Balemans","sequence":"additional","affiliation":[{"name":"Department of Pediatrics St. Antonius Hospital PO Box 2500 3430 EM Nieuwegein The 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