{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:31:26Z","timestamp":1791325886664,"version":"4.3.1"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,1,26]],"date-time":"2017-01-26T00:00:00Z","timestamp":1485388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>OBJECTIVES<\/jats:title><jats:p>To assess lung function and long\u2010term respiratory outcomes in extremely low birth weight (ELBW) survivors.<\/jats:p><\/jats:sec><jats:sec><jats:title>WORKING HYPOTHESIS<\/jats:title><jats:p>ELBW, especially with respiratory complications in the neonatal period, affects lung function at a later age.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN<\/jats:title><jats:p>Longitudinal retrospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>PATIENT\u2010SUBJECT SELECTION<\/jats:title><jats:p>Lung function was evaluated in 89 ELBW survivors (at ages 8 and 12) with or without a history of bronchopulmonary dysplasia (BPD) or a bubbly\/cystic lung appearance in the neonatal period.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODOLOGY<\/jats:title><jats:p>FVC, FEV<jats:sub>1<\/jats:sub>, FEF<jats:sub>50<\/jats:sub>, and FEF<jats:sub>75<\/jats:sub> were measured using spirometry. Two\u2010way repeated\u2010measures ANOVA was used to compare lung function and deterioration time course from 8 to 12 years of age.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Lung function variables were significantly and positively correlated between 8 and 12 years: %FVC (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.558), %FEV<jats:sub>1<\/jats:sub> (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.539), %FEF<jats:sub>50<\/jats:sub> (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.412), and %FEF<jats:sub>75<\/jats:sub> (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.429). Lung function values were lower than Japanese reference values, especially in children with a history of severe BPD or a bubbly\/cystic appearance. %FEV<jats:sub>1<\/jats:sub> and FEV<jats:sub>1<\/jats:sub>\/FVC ratio worsened from 8 to 12 years of age: 83.0\u2009\u00b1\u200917.0% versus 76.6\u2009\u00b1\u200917.8% (mean difference, 95%CI: \u22126.43, \u22129.10 to \u22123.75) and 84.0\u2009\u00b1\u200910.1% versus 78.2\u2009\u00b1\u200913.4% (mean difference, 95%CI: \u22125.82, \u22128.56 to \u22123.08), regardless of whether or not there was a history of neonatal respiratory disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>In ELBW survivors, the obstructive pattern of lung function impairment deteriorated from 8 to 12 years of age, independent of the presence of severe BPD or bubbly\/cystic appearance in the neonatal period.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.23669","type":"journal-article","created":{"date-parts":[[2017,1,26]],"date-time":"2017-01-26T14:06:44Z","timestamp":1485439604000},"page":"779-786","source":"Crossref","is-referenced-by-count":48,"title":["Longitudinal impairment of lung function in school\u2010age children with extremely low birth weights"],"prefix":"10.1002","volume":"52","author":[{"given":"Katsuya","family":"Hirata","sequence":"first","affiliation":[{"name":"Department of Neonatal Medicine Osaka Medical Center and Research Institute for Maternal and Child Health Izumi Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Nishihara","sequence":"additional","affiliation":[{"name":"Department of Neonatal Medicine Osaka Medical Center and Research Institute for Maternal and Child Health Izumi Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Neonatal Medicine Osaka Medical Center and Research Institute for Maternal and Child Health Izumi Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Shiraishi","sequence":"additional","affiliation":[{"name":"Department of Neonatal Medicine Osaka Medical Center and Research Institute for Maternal and Child Health Izumi Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Hirano","sequence":"additional","affiliation":[{"name":"Department of Neonatal Medicine Osaka Medical Center and Research Institute for Maternal and Child Health Izumi Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Kitajima","sequence":"additional","affiliation":[{"name":"Department of Neonatal Medicine Osaka Medical Center and Research Institute for Maternal and Child Health Izumi Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Fujimura","sequence":"additional","affiliation":[{"name":"Department of Neonatal Medicine Osaka Medical Center and Research Institute for Maternal and Child Health Izumi Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12633-5"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2008.140830"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200912-1806OC"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.22619"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20412"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1067\/S0022-3476(03)00413-X"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.07.045"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2013.10.006"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.22676"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.23153"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2012-203079"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.23422"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2016-208524"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200705-701OC"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-2522"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2012-202980"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-2651"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2014-306931"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.23393"},{"key":"e_1_2_8_21_1","doi-asserted-by":"crossref","unstructured":"Standardization of Spirometry 1994 Update. 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