{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T09:49:44Z","timestamp":1774691384617,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,2,6]],"date-time":"2017-02-06T00:00:00Z","timestamp":1486339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Despite the near universal adaptation of gentle mechanical ventilation, surfactant use and non\u2010invasive respiratory support, bronchopulmonary dysplasia (BPD) remains one of the most common respiratory morbidities in very low birth weight (VLBW) infants. Thus, the objective of this review was to evaluate the efficacy of intra\u2010tracheal administration of budesonide\u2010surfactant mixture in preventing bronchopulmonary dysplasia (BPD) in very low birth weight (VLBW) infants. MEDLINE, EMBASE, and PubMed were searched for randomized clinical trials in which intra\u2010tracheal administration of budesonide\u2010surfactant was used to prevent BPD in infants. The primary outcomes were BPD and composite outcome of death or BPD. Meta\u2010analysis of the two clinical trials revealed that infants who received intra\u2010tracheal instillation of budesonide\u2010surfactant mixture demonstrated 43% reduction in the risk of BPD (RR: 0.57; 95%CI: 0.43\u20100.76, NNT\u2009=\u20095). Although mortality was not different between the groups (OR: 0.61; 95%CI: 0.34\u20101.04), a 40% reduction was observed in the composite outcome of death or BPD in the budesonide\u2010surfactant group (RR: 0.60; 95%CI: 0.49\u20100.74, NNT\u2009=\u20093). Thus, this review concludes that intra\u2010tracheal administration of budesonide\u2010surfactant combination was associated with decreased incidence of BPD alone or composite outcome of death or BPD in VLBW infants though there is a need for larger trials before it can be recommended as a standard of care.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.23680","type":"journal-article","created":{"date-parts":[[2017,2,6]],"date-time":"2017-02-06T16:02:57Z","timestamp":1486396977000},"page":"968-975","source":"Crossref","is-referenced-by-count":79,"title":["Intratracheal Administration of Budesonide\u2010Surfactant in Prevention of Bronchopulmonary Dysplasia in Very Low Birth Weight Infants: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"52","author":[{"given":"Rohini","family":"Venkataraman","sequence":"first","affiliation":[{"name":"Department of Pediatrics University of Calgary Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Majeeda","family":"Kamaluddeen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Calgary Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shabih U.","family":"Hasan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Calgary Calgary Alberta Canada"},{"name":"Alberta Children's Hospital Research Institute University of Calgary Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen Lee","family":"Robertson","sequence":"additional","affiliation":[{"name":"Health Sciences Library University of Calgary Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhay","family":"Lodha","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Calgary Calgary Alberta Canada"},{"name":"Alberta Children's Hospital Research Institute University of Calgary Calgary Alberta Canada"},{"name":"Department of Community Health Sciences University of Calgary Calgary Alberta Canada"},{"name":"Department of Pediatrics Peter Lougheed Centre Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,2,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4755-10-S1-S2"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60820-4"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e7976"},{"key":"e_1_2_8_5_1","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1001\/jama.2015.10244","article-title":"Trends in care practices, morbidity, and mortality of extremely preterm neonates, 1993\u20132012","volume":"314","author":"Stoll BJ","journal-title":"JAMA"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201312-424LD"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2009.08.007"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1754.1999.00308.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/2047-783X-16-5-223"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2015.7"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0090843"},{"key":"e_1_2_8_12_1","first-page":"CD001146","article-title":"Early (<8 days) postnatal corticosteroids for preventing chronic lung disease in preterm infants","volume":"5","author":"Doyle LW","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.104.1.91"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1501917"},{"key":"e_1_2_8_15_1","unstructured":"LinY\u2010J. 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