{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T17:34:21Z","timestamp":1749058461640,"version":"3.37.3"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,6,13]],"date-time":"2017-06-13T00:00:00Z","timestamp":1497312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["NSC 99\u20102314\u2010B\u2010010\u2010002\u2010MY3","MOST 105\u20102314\u2010B\u2010010\u2010044"],"award-info":[{"award-number":["NSC 99\u20102314\u2010B\u2010010\u2010002\u2010MY3","MOST 105\u20102314\u2010B\u2010010\u2010044"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Severe inflammation plays a vital role in the pathogenesis of meconium aspiration syndrome (MAS). Intratracheal (IT) instillation of corticosteroids may be beneficial for MAS in optimizing local effect and reducing systemic adverse effects, but the optimum dosing course remains open to question.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty meconium\u2010injured newborn piglets were enrolled into six study groups. The first four groups consisted of the IT instillation of 0.25\/0.5\u2009mg\/kg using either one (IT\u2010B251\/IT\u2010B501) or two (IT\u2010B252\/IT\u2010B502) doses of budesonide, while the other two groups were the intravenous (IV) dexamethasone (0.5\u2009mg\/kg) (IV\u2010Dex) group and the control group (Ctrl). Vital signs and cardiopulmonary functions were monitored throughout the experiments. Pulmonary histology was examined after completing the experiments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both the IV\u2010Dex and IT\u2010B501 groups got significant improvement in oxygenation (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Lung compliance became worse after one dose of 0.25\u2009mg\/kg of IT budesonide. Pulmonary histology revealed that there were significantly lower lung injury scores for all treatment groups compared to control group, especially at the non\u2010dependent sites of both the IT\u2010B501 and IT\u2010B502 groups. There was no significant difference between double\u2010 and single\u2010dose groups, no matter whether 0.25 or 0.5\u2009mg\/kg of budesonide was used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>IT instillation of one dose of 0.5\u2009mg\/kg budesonide is beneficial in treating meconium\u2010injured piglet lungs during the first 8\u2009h of injury, but a second dose at an interval of 4\u2009h does not have a superior beneficial effect compared to one dose.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.23697","type":"journal-article","created":{"date-parts":[[2017,6,13]],"date-time":"2017-06-13T12:20:34Z","timestamp":1497356434000},"page":"891-899","source":"Crossref","is-referenced-by-count":7,"title":["Comparison of different dosing strategies of intratracheally instilled budesonide on meconium injured piglet lungs"],"prefix":"10.1002","volume":"52","author":[{"given":"Chih\u2010Hsueh","family":"Lin","sequence":"first","affiliation":[{"name":"School of Medicine, Institute of Physiology National Yang\u2010Ming University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7427-0367","authenticated-orcid":false,"given":"Mei\u2010Jy","family":"Jeng","sequence":"additional","affiliation":[{"name":"School of Medicine, Institute of Emergency and Critical Care Medicine National Yang\u2010Ming University Taipei Taiwan"},{"name":"Department of Pediatrics, Children's Medical Center Taipei Veterans General Hospital Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Chiang","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Medicine Fu Jen Catholic University New Taipei Taiwan"},{"name":"Department of Education Taipei Veterans General Hospital Taiwan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Hsuan","family":"Hsiao","sequence":"additional","affiliation":[{"name":"School of Medicine Fu Jen Catholic University New Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu Ru","family":"Kou","sequence":"additional","affiliation":[{"name":"School of Medicine, Institute of Physiology National Yang\u2010Ming University Taipei Taiwan"},{"name":"School of Medicine, Institute of Emergency and Critical Care Medicine National Yang\u2010Ming University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,6,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-2215"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/359571"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2008.241"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000369373"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/204831"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000082017.97479.39"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20675"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.10.009"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.23349"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2013.02.025"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200106000-00018"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2004.03.017"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20330"},{"key":"e_1_2_8_15_1","first-page":"CD003485","article-title":"Steroid therapy for meconium aspiration syndrome in newborn infants","author":"Ward M","year":"2003","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.83.3.F177"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2003.028696"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-011-1453-2"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002058.pub2:Cd002058"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/fmm035"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2014.985202"},{"key":"e_1_2_8_22_1","first-page":"379","article-title":"Single\u2010dose versus two\u2010dose dexamethasone effects on lung inflammation and airway reactivity in meconium\u2010instilled rabbits","volume":"58","author":"Mokra D","year":"2007","journal-title":"J Physiol Pharmacol"},{"key":"e_1_2_8_23_1","first-page":"389","article-title":"Intratracheally administered corticosteroids improve lung function in meconium\u2010instilled rabbits","volume":"58","author":"Mokra D","year":"2007","journal-title":"J Physiol Pharmacol"},{"key":"e_1_2_8_24_1","unstructured":"Animals CftUotGftCaUoL. 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