{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T09:25:22Z","timestamp":1783070722039,"version":"3.54.6"},"reference-count":44,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,4,13]],"date-time":"2017-04-13T00:00:00Z","timestamp":1492041600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2017,4,13]],"date-time":"2017-04-13T00:00:00Z","timestamp":1492041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Dutch Foundation for Scientific Research"},{"name":"Topzorg","award":["842002002"],"award-info":[{"award-number":["842002002"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Pulmonol"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1002\/ppul.23704","type":"journal-article","created":{"date-parts":[[2017,4,13]],"date-time":"2017-04-13T18:13:39Z","timestamp":1492107219000},"page":"1206-1211","source":"Crossref","is-referenced-by-count":31,"title":["Screening children for pulmonary arteriovenous malformations: Evaluation of 18 years of experience"],"prefix":"10.1002","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6939-8406","authenticated-orcid":false,"given":"Anna E.","family":"Hosman","sequence":"first","affiliation":[{"name":"Department of Pulmonology; St Antonius Hospital; Nieuwegein The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Els M.","family":"de Gussem","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine; University of Manitoba; Winnipeg Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter A. F.","family":"Balemans","sequence":"additional","affiliation":[{"name":"Department of Pediatrics; St Antonius Hospital; Nieuwegein The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9anne","family":"Gauthier","sequence":"additional","affiliation":[{"name":"Department of Pulmonology; Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al; Montr\u00e9al Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cees J. J.","family":"Westermann","sequence":"additional","affiliation":[{"name":"Department of Pulmonology; St Antonius Hospital; Nieuwegein The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Repke J.","family":"Snijder","sequence":"additional","affiliation":[{"name":"Department of Pulmonology; St Antonius Hospital; Nieuwegein The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco C.","family":"Post","sequence":"additional","affiliation":[{"name":"Department of Cardiology; St Antonius Hospital; Nieuwegein The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes J.","family":"Mager","sequence":"additional","affiliation":[{"name":"Department of Pulmonology; St Antonius Hospital; Nieuwegein The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,13]]},"reference":[{"key":"10.1002\/ppul.23704-BIB0001|ppul23704-cit-0001","first-page":"3","article-title":"Epidemiological investigation of rendu-osler disease in france: its geographical distribution and prevalence","volume":"44","author":"Bideau","year":"1989","journal-title":"Popul"},{"key":"10.1002\/ppul.23704-BIB0002|ppul23704-cit-0002","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1002\/ajmg.a.10002","article-title":"The prevalence and manifestations of hereditary hemorrhagic telangiectasia in the afro-caribbean population of the netherlands antilles: a family screening","volume":"116A","author":"Westermann","year":"2003","journal-title":"Am J Med Genet A"},{"key":"10.1002\/ppul.23704-BIB0003|ppul23704-cit-0003","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1046\/j.1365-2796.1999.00398.x","article-title":"Hereditary haemorrhagic telangiectasia: a population-based study of prevalence and mortality in danish patients","volume":"245","author":"Kjeldsen","year":"1999","journal-title":"J Intern Med"},{"key":"10.1002\/ppul.23704-BIB0004|ppul23704-cit-0004","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/ng0294-197","article-title":"A disease locus for hereditary haemorrhagic telangiectasia maps to chromosome 9q33-34","volume":"6","author":"McDonald","year":"1994","journal-title":"Nat Genet"},{"key":"10.1002\/ppul.23704-BIB0005|ppul23704-cit-0005","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/ng0696-189","article-title":"Mutations in the activin receptor-like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2","volume":"13","author":"Johnson","year":"1996","journal-title":"Nat Genet"},{"key":"10.1002\/ppul.23704-BIB0006|ppul23704-cit-0006","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/ng0294-205","article-title":"A gene for hereditary haemorrhagic telangiectasia maps to chromosome 9q3","volume":"6","author":"Shovlin","year":"1994","journal-title":"Nat Genet"},{"key":"10.1002\/ppul.23704-BIB0007|ppul23704-cit-0007","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/S0140-6736(04)15732-2","article-title":"A combined syndrome of juvenile polyposis and hereditary haemorrhagic telangiectasia associated with mutations in MADH4 (SMAD4)","volume":"363","author":"Gallione","year":"2004","journal-title":"Lancet"},{"key":"10.1002\/ppul.23704-BIB0008|ppul23704-cit-0008","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.blre.2010.07.001","article-title":"Hereditary haemorrhagic telangiectasia: pathophysiology, diagnosis and treatment","volume":"24","author":"Shovlin","year":"2010","journal-title":"Blood Rev"},{"key":"10.1002\/ppul.23704-BIB0009|ppul23704-cit-0009","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1378\/chest.13-0716","article-title":"Role of transthoracic contrast echocardiography in the clinical diagnosis of hereditary hemorrhagic telangiectasia","volume":"144","author":"Velthuis","year":"2013","journal-title":"Chest"},{"key":"10.1002\/ppul.23704-BIB0010|ppul23704-cit-0010","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1001\/archpedi.160.6.596","article-title":"Symptomatic children with hereditary hemorrhagic telangiectasia: a pediatric center experience","volume":"160","author":"Mei-Zahav","year":"2006","journal-title":"Arch Pediatr Adolesc Med"},{"key":"10.1002\/ppul.23704-BIB0011|ppul23704-cit-0011","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1002\/(SICI)1096-8628(20000306)91:1<66::AID-AJMG12>3.0.CO;2-P","article-title":"Diagnostic criteria for hereditary hemorrhagic telangiectasia (rendu-osler-weber syndrome)","volume":"91","author":"Shovlin","year":"2000","journal-title":"Am J Med Genet"},{"key":"10.1002\/ppul.23704-BIB0012|ppul23704-cit-0012","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1378\/chest.09-1849","article-title":"Real prevalence of pulmonary right-to-left shunt according to genotype in patients with hereditary hemorrhagic telangiectasia: a transthoracic contrast echocardiography study","volume":"138","author":"van Gent","year":"2010","journal-title":"Chest"},{"key":"10.1002\/ppul.23704-BIB0013|ppul23704-cit-0013","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1002\/ajmg.a.31101","article-title":"Genotype-phenotype correlation in hereditary hemorrhagic telangiectasia: mutations and manifestations","volume":"140A","author":"Bayrak-Toydemir","year":"2006","journal-title":"Am J Med Genet A"},{"key":"10.1002\/ppul.23704-BIB0014|ppul23704-cit-0014","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/j.1365-2796.2005.01555.x","article-title":"Clinical symptoms according to genotype amongst patients with hereditary haemorrhagic telangiectasia","volume":"258","author":"Kjeldsen","year":"2005","journal-title":"J Intern Med"},{"key":"10.1002\/ppul.23704-BIB0015|ppul23704-cit-0015","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1136\/jmg.2005.035451","article-title":"Genotype-phenotype relationship in hereditary haemorrhagic telangiectasia","volume":"43","author":"Letteboer","year":"2006","journal-title":"J Med Genet"},{"key":"10.1002\/ppul.23704-BIB0016|ppul23704-cit-0016","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/ajmg.1320320302","article-title":"Age-related clinical profile of hereditary hemorrhagic telangiectasia in an epidemiologically recruited population","volume":"32","author":"Plauchu","year":"1989","journal-title":"Am J Med Genet"},{"key":"10.1002\/ppul.23704-BIB0017|ppul23704-cit-0017","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1136\/jmg.2009.069013","article-title":"International guidelines for the diagnosis and management of hereditary haemorrhagic telangiectasia","volume":"48","author":"Faughnan","year":"2011","journal-title":"J Med Genet"},{"key":"10.1002\/ppul.23704-BIB0018|ppul23704-cit-0018","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1164\/rccm.200310-1441OC","article-title":"Pulmonary arteriovenous malformations in patients with hereditary hemorrhagic telangiectasia","volume":"169","author":"Cottin","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1002\/ppul.23704-BIB0019|ppul23704-cit-0019","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/echo.12615","article-title":"Reliability of contrast echocardiography to rule out pulmonary arteriovenous malformations and avoid CT irradiation in pediatric patients with hereditary hemorrhagic telangiectasia","volume":"32","author":"Karam","year":"2015","journal-title":"Echocardiography"},{"key":"10.1002\/ppul.23704-BIB0020|ppul23704-cit-0020","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.jpeds.2011.11.038","article-title":"Utility of contrast echocardiography for pulmonary arteriovenous malformation screening in pediatric hereditary hemorrhagic telangiectasia","volume":"160","author":"Al-Saleh","year":"2012","journal-title":"J Pediatr"},{"key":"10.1002\/ppul.23704-BIB0021|ppul23704-cit-0021","doi-asserted-by":"crossref","first-page":"S195","DOI":"10.1111\/echo.12839","article-title":"Clinical consideration for techniques to detect and quantify blood flow through intrapulmonary arteriovenous anastomoses: lessons from physiological studies","volume":"32","author":"Duke","year":"2015","journal-title":"Echocardiography"},{"key":"10.1002\/ppul.23704-BIB0022|ppul23704-cit-0022","doi-asserted-by":"crossref","first-page":"4537","DOI":"10.1113\/jphysiol.2014.274829","article-title":"Increased cardiac output, not pulmonary artery systolic pressure, increases intrapulmonary shunt in healthy humans breathing room air and 40% O2","volume":"592","author":"Elliott","year":"2014","journal-title":"J Physiol"},{"key":"10.1002\/ppul.23704-BIB0023|ppul23704-cit-0023","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1161\/STROKEAHA.109.549683","article-title":"Cerebral ischemic events associated with \u2018bubble study\u2019 for identification of right to left shunts","volume":"40","author":"Romero","year":"2009","journal-title":"Stroke"},{"key":"10.1002\/ppul.23704-BIB0024|ppul23704-cit-0024","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1001\/archderm.136.6.732","article-title":"Value of capillary microscopy in the diagnosis of hereditary hemorrhagic telangiectasia","volume":"136","author":"Mager","year":"2000","journal-title":"Arch Dermatol"},{"key":"10.1002\/ppul.23704-BIB0025|ppul23704-cit-0025","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1093\/qjmed\/hci115","article-title":"Capillaroscopy of the dorsal skin of the hands in hereditary hemorrhagic telangiectasia","volume":"98","author":"Pasculli","year":"2005","journal-title":"QJM"},{"key":"10.1002\/ppul.23704-BIB0026|ppul23704-cit-0026","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1016\/j.amjcard.2010.12.052","article-title":"Relation between migraine and size of echocardiographic intrapulmonary right-to-left shunt","volume":"107","author":"van Gent","year":"2011","journal-title":"Am J Cardiol"},{"key":"10.1002\/ppul.23704-BIB0027|ppul23704-cit-0027","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1212\/WNL.0000000000002538","article-title":"Systemic right-to-left shunts, ischemic brain lesions, and persistent migraine activity","volume":"86","author":"Koppen","year":"2016","journal-title":"Neurology"},{"key":"10.1002\/ppul.23704-BIB0028|ppul23704-cit-0028","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1067\/mhj.2001.112682","article-title":"Contrast echocardiography for detection of pulmonary arteriovenous malformations","volume":"141","author":"Nanthakumar","year":"2001","journal-title":"Am Heart J"},{"key":"10.1002\/ppul.23704-BIB0029|ppul23704-cit-0029","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3171\/2013.10.JNS122402","article-title":"Cerebral vascular malformations in hereditary hemorrhagic telangiectasia","volume":"120","author":"Woodall","year":"2014","journal-title":"J Neurosurg"},{"key":"10.1002\/ppul.23704-BIB0030|ppul23704-cit-0030","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1086\/511645","article-title":"Hemorrhagic hereditary telangiectasia (rendu-osler disease) and infectious diseases: an underestimated association","volume":"44","author":"Dupuis-Girod","year":"2007","journal-title":"Clin Infect Dis"},{"key":"10.1002\/ppul.23704-BIB0031|ppul23704-cit-0031","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.clineuro.2011.10.036","article-title":"Cerebral abscesses in hereditary haemorrhagic telangiectasia: a clinical and microbiological evaluation","volume":"114","author":"Mathis","year":"2012","journal-title":"Clin Neurol Neurosurg"},{"key":"10.1002\/ppul.23704-BIB0032|ppul23704-cit-0032","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/ane.12167","article-title":"Cerebral abscesses among danish patients with hereditary haemorrhagic telangiectasia","volume":"129","author":"Kjeldsen","year":"2014","journal-title":"Acta Neurol Scand"},{"key":"10.1002\/ppul.23704-BIB0033|ppul23704-cit-0033","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1136\/thx.2007.087452","article-title":"Primary determinants of ischaemic stroke\/brain abscess risks are independent of severity of pulmonary arteriovenous malformations in hereditary haemorrhagic telangiectasia","volume":"63","author":"Shovlin","year":"2008","journal-title":"Thorax"},{"key":"10.1002\/ppul.23704-BIB0034|ppul23704-cit-0034","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1183\/09031936.00030009","article-title":"Screening for pulmonary and cerebral arteriovenous malformations in children with hereditary haemorrhagic telangiectasia","volume":"34","author":"Al-Saleh","year":"2009","journal-title":"European Respiratory Journal"},{"key":"10.1002\/ppul.23704-BIB0035|ppul23704-cit-0035","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jpeds.2014.03.040","article-title":"The diagnostic yield of rescreening for arteriovenous malformations in children with hereditary hemorrhagic telangiectasia","volume":"165","author":"Latino","year":"2014","journal-title":"J Pediatr"},{"key":"10.1002\/ppul.23704-BIB0036|ppul23704-cit-0036","doi-asserted-by":"crossref","first-page":"f2360","DOI":"10.1136\/bmj.f2360","article-title":"Cancer risk in 680,000 people exposed to computed tomography scans in childhood or adolescence: data linkage study of 11 million australians","volume":"346","author":"Mathews","year":"2013","journal-title":"BMJ"},{"key":"10.1002\/ppul.23704-BIB0037|ppul23704-cit-0037","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3389\/fgene.2015.00101","article-title":"Circulatory contributors to the phenotype in hereditary hemorrhagic telangiectasia","volume":"6","author":"Shovlin","year":"2015","journal-title":"Front Genet"},{"key":"10.1002\/ppul.23704-BIB0038|ppul23704-cit-0038","doi-asserted-by":"crossref","first-page":"e200","DOI":"10.1097\/MPH.0000000000000254","article-title":"Pulmonary arteriovenous malformations and cerebral abscess recurrence in a child with hereditary hemorrhagic telangiectasia","volume":"37","author":"Giordano","year":"2015","journal-title":"J Pediatr Hematol Oncol"},{"key":"10.1002\/ppul.23704-BIB0039|ppul23704-cit-0039","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jpeds.2013.02.009","article-title":"Hereditary hemorrhagic telangiectasia: arteriovenous malformations in children","volume":"163","author":"Giordano","year":"2013","journal-title":"J Pediatr"},{"key":"10.1002\/ppul.23704-BIB0040|ppul23704-cit-0040","first-page":"537","article-title":"Correlation of oxygen saturation and serious adverse events in pediatric patients with documented or suspected pulmonary arteriovenous malformation","volume":"18","author":"Ibrahim","year":"2015","journal-title":"Angiogenesis"},{"key":"10.1002\/ppul.23704-BIB0041|ppul23704-cit-0041","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.jpeds.2004.08.046","article-title":"Pulmonary arteriovenous malformations in children: outcomes of transcatheter embolotherapy","volume":"145","author":"Faughnan","year":"2004","journal-title":"J Pediatr"},{"key":"10.1002\/ppul.23704-BIB0042|ppul23704-cit-0042","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.jvir.2015.02.016","article-title":"Reperfusion rates of pulmonary arteriovenous malformations after coil embolization: evaluation with time-resolved MR angiography or pulmonary angiography","volume":"26","author":"Shimohira","year":"2015","journal-title":"J Vasc Interv Radiol"},{"key":"10.1002\/ppul.23704-BIB0043|ppul23704-cit-0043","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1097\/01.RVI.0000126811.05229.B6","article-title":"Embolotherapy of pulmonary arteriovenous malformations: long-term results in 112 patients","volume":"15","author":"Mager","year":"2004","journal-title":"J Vasc Interv Radiol"},{"key":"10.1002\/ppul.23704-BIB0044|ppul23704-cit-0044","first-page":"538","article-title":"Long-term embolotherapy treatment outcomes of pulmonary arteriovenous malformations in children with hereditary hemorrhagic telangiectasia","volume":"18","author":"Crawford","year":"2015","journal-title":"Angiogenesis"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.23704","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/ppul.23704","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,3]],"date-time":"2021-07-03T22:00:55Z","timestamp":1625349655000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.23704"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,13]]},"references-count":44,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2017,9]]}},"URL":"https:\/\/doi.org\/10.1002\/ppul.23704","archive":["Portico"],"relation":{},"ISSN":["8755-6863"],"issn-type":[{"value":"8755-6863","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4,13]]}}}