{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:14:32Z","timestamp":1790835272002,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,9,7]],"date-time":"2017-09-07T00:00:00Z","timestamp":1504742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Sophia Stichting Wetenschappelijk Onderzoek","award":["679"],"award-info":[{"award-number":["679"]}]},{"name":"Nederlandse Cystic Fibrosis Stichting"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate lung disease progression using airway and artery (AA) dimensions on chest CT over 2\u2010year interval in young CF patients longitudinally and compare to disease controls cross\u2010sectionally.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective analysis of pressure controlled end\u2010inspiratory CTs, 12 routine baseline (CT<jats:sub>1<\/jats:sub>) and follow up (CT<jats:sub>2<\/jats:sub>) from AREST CF cohort; 12 disease controls with normal CT. All visible AA\u2010pairs were measured perpendicular to the airway axis. Inner and outer airway diameters and wall (outer\u2010inner radius) thickness were divided by adjacent arteries to compute A<jats:sub>in<\/jats:sub>A\u2010, A<jats:sub>out<\/jats:sub>A\u2010, and A<jats:sub>WT<\/jats:sub>A\u2010ratios, respectively. Differences between CF and control data were assessed using mixed effects models predicting AA\u2010ratios per segmental generation (SG). Power calculations were performed with 80% power and <jats:italic>\u0251<\/jats:italic>\u2009=\u20090.05.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>CF, median age CT<jats:sub>1<\/jats:sub> 2 years; CT<jats:sub>2<\/jats:sub> 3.9 years, 5 males. Controls, median age 2.9 years, 10 males. Total of 4798 AA\u2010pairs measured. Cross\u2010sectionally: A<jats:sub>in<\/jats:sub>A\u2010ratio showed no difference between controls and CF CT<jats:sub>1<\/jats:sub> or CT<jats:sub>2<\/jats:sub>. A<jats:sub>out<\/jats:sub>A\u2010ratio was significantly higher in CF CT<jats:sub>1<\/jats:sub> (SG 2\u20104) and CT<jats:sub>2<\/jats:sub> (SG 2\u20105) compared to controls. A<jats:sub>WT<\/jats:sub>A\u2010ratio was increased for CF CT<jats:sub>1<\/jats:sub> (SG 1\u20105) and CT<jats:sub>2<\/jats:sub> (SG 2\u20106) compared to controls. CF longitudinally: A<jats:sub>in<\/jats:sub>A\u2010ratio was significantly higher at CT<jats:sub>2<\/jats:sub> compared to CT<jats:sub>1<\/jats:sub>. Increase in A<jats:sub>out<\/jats:sub>A\u2010ratio at CT<jats:sub>2<\/jats:sub> compared to CT<jats:sub>1<\/jats:sub> was visible in SG \u22654. Sample sizes of 21 and 58 would be necessary for 50% and 30% A<jats:sub>out<\/jats:sub>A\u2010ratio reductions, respectively, between CF CT<jats:sub>2<\/jats:sub> and controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>AA\u2010ratio differences were present in young CF patients relative to disease controls. A<jats:sub>out<\/jats:sub>A\u2010ratio as an objective parameter for bronchiectasis could reduce sample sizes for clinical trials.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.23787","type":"journal-article","created":{"date-parts":[[2017,9,7]],"date-time":"2017-09-07T18:30:21Z","timestamp":1504809021000},"page":"1414-1423","source":"Crossref","is-referenced-by-count":41,"title":["Quantitative assessment of airway dimensions in young children with cystic fibrosis lung disease using chest computed tomography"],"prefix":"10.1002","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8846-3517","authenticated-orcid":false,"given":"Wieying","family":"Kuo","sequence":"first","affiliation":[{"name":"Department of Pediatric Pulmonology and Allergology Erasmus MC\u2014Sophia Children's Hospital Rotterdam The Netherlands"},{"name":"Department of Radiology Erasmus MC Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Soffers","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology and Allergology Erasmus MC\u2014Sophia Children's Hospital Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni\u2010Rosalina","family":"Andrinopoulou","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Erasmus MC Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3727-5131","authenticated-orcid":false,"given":"Tim","family":"Rosenow","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute The University of Western Australia Perth Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarath","family":"Ranganathan","sequence":"additional","affiliation":[{"name":"Infection and Immunity Theme Murdoch Children's Research Institute Melbourne Australia"},{"name":"Department of Paediatrics University of Melbourne Australia"},{"name":"Department of Respiratory Medicine Royal Children's Hospital Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidija","family":"Turkovic","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute The University of Western Australia Perth Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen M.","family":"Stick","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute The University of Western Australia Perth Australia"},{"name":"Princess Margaret Hospital for Children Perth Western Australia Australia"},{"name":"School of Paediatrics and Child Health University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harm A.W.M.","family":"Tiddens","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology and Allergology Erasmus MC\u2014Sophia Children's Hospital Rotterdam The Netherlands"},{"name":"Department of Radiology Erasmus MC Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of AREST CF","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2011-200912"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200901-0069OC"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2003.09.026"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.23146"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12521"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201407-338OC"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00108212"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-015-3850-9"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2013.09.003"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.191.3.8184044"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-017-4819-7"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2016.05.015"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200410-1311OC"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1301725"},{"key":"e_1_2_7_16_1","first-page":"197","volume-title":"Atlas of human anatomy","author":"Netter FH","year":"2014"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyv113"},{"key":"e_1_2_7_18_1","unstructured":"R Foundation for statistical Computing. 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