{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T19:37:46Z","timestamp":1790019466500,"version":"4.0.1"},"reference-count":37,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,9,26]],"date-time":"2017-09-26T00:00:00Z","timestamp":1506384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004431","name":"Fondation de France","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004431","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Childhood recurrent wheezing and consequently asthma corresponds to various phenotypes. Our aim was to link genetic variants of asthma candidate genes to the phenotypes of early onset wheezing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study design<\/jats:title><jats:p>We included very young consecutive children presenting with recurrent wheezing who had been evaluated for the severity of wheezing, associated atopic comorbidities, and tested for biomarkers of atopy and inflammation. All were genotyped for 16 single nucleotide polymorphisms (SNPs) linked with asthma or atopy. An unsupervised hierarchical bottom\u2010up method was used for clustering the phenotypes and a multinomial logistic regression was performed for each individual SNP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We replicated the three phenotypes previously described Trousseau Asthma Program in 317 children aged 21.5\u2009\u00b1\u20097.9 months: cluster 1 (nonatopic uncontrolled severe wheeze), <jats:italic>n<\/jats:italic>\u2009=\u2009207, a severe viral\u2010induced wheeze, cluster 2 (atopic multiple trigger wheeze), <jats:italic>n<\/jats:italic>\u2009=\u200961, with multiple allergic comorbidities, and cluster 3 (episodic viral wheeze), <jats:italic>n<\/jats:italic>\u2009=\u200949, a mild viral\u2010induced wheeze. The TT\u2010genotype of the IL\u20104 rs2070874 polymorphism was significantly associated with the nonatopic uncontrolled severe wheeze compared to the episodic viral wheeze (OR 7.9; CI95% [2.5\u201025.3]; <jats:italic>P<\/jats:italic>\u2009=\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Association between the TT\u2010genotype of IL\u20104 rs2070874 polymorphism and a severe phenotype of viral\u2010induced wheeze further underlines the role IL\u20104 plays in the inflammation pathway leading to viral respiratory infections.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.23834","type":"journal-article","created":{"date-parts":[[2017,9,26]],"date-time":"2017-09-26T16:52:50Z","timestamp":1506444770000},"page":"1435-1442","source":"Crossref","is-referenced-by-count":10,"title":["The IL\u20104 rs2070874 polymorphism may be associated with the severity of recurrent viral\u2010induced 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