{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T17:22:45Z","timestamp":1768411365269,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,11,8]],"date-time":"2017-11-08T00:00:00Z","timestamp":1510099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Improved exercise capacity (EC) and normal glucose tolerance (NGT) are independently associated with favorable outcomes in CF, however, little information on this relationship exists in patients with CF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cardiopulmonary exercise tests, oral glucose tolerance tests (OGTT), and HbA1c values measured within a 12\u2010month period were evaluated on 83 pediatric patients diagnosed with CF. Patients were categorized as having NGT, abnormal glucose tolerance (AGT), or CF\u2010related diabetes (CFRD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>EC decreased as severity of glucose intolerance increased across NGT, AGT, and CFRD groups (<jats:italic>P<\/jats:italic>\u2009=\u20090.02). Compared to patients with NGT, patients with CFRD had lower peak VO<jats:sub>2\u2009<\/jats:sub>mL\/kg\/min (33.0\u2009\u00b1\u20097.3 vs 41.3\u2009\u00b1\u20099.4, <jats:italic>P<\/jats:italic>\u2009=\u20090.01), lower VO<jats:sub>2<\/jats:sub>% (81\u2009\u00b1\u200920 vs 93\u2009\u00b1\u200917, <jats:italic>P<\/jats:italic>\u2009=\u20090.03), and higher HbA1c (6.9\u2009\u00b1\u20091.7 vs 5.4\u2009\u00b1\u20090.4, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). There was a positive association with age and FEV<jats:sub>1<\/jats:sub>% with EC in the 17 patients with CFRD. In the 66 patients without diabetes, peak EC was positively associated with FEV<jats:sub>1<\/jats:sub>% and negatively associated with age, fasting insulin, and insulin 120\u2009min. After accounting for age and FEV<jats:sub>1<\/jats:sub>%, multivariate analyses indicated that insulin and glucose values at 120\u2009min predicted EC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These data provide evidence that poor glucose tolerance is associated with lower EC in pediatric patients with CF. There was a significant relationship between glucose and insulin values obtained by OGTT with EC in a sample of non\u2010diabetic patients with preserved lung function. Future studies are warranted to confirm these findings and investigate the potential role of exercise in the management or prevention of CFRD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.23906","type":"journal-article","created":{"date-parts":[[2017,11,8]],"date-time":"2017-11-08T09:28:40Z","timestamp":1510133320000},"page":"154-161","source":"Crossref","is-referenced-by-count":11,"title":["Relationship between exercise capacity and glucose tolerance in cystic fibrosis"],"prefix":"10.1002","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1483-0238","authenticated-orcid":false,"given":"Karla","family":"Foster","sequence":"first","affiliation":[{"name":"Division of Pulmonary Medicine Cincinnati Children's Hospital Medical Center Cincinnati Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guixia","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Biostatistics and Epidemiology Cincinnati Children's Hospital Medical Center 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