{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:18:54Z","timestamp":1790623134244,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T00:00:00Z","timestamp":1519689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006706","name":"Tampereen Tuberkuloosis\u00e4\u00e4ti\u00d6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006706","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The transition from early childhood wheezing to persistent asthma is linked to lung function impairment over time. Little is known how the methods used to study lung function at different ages correlate longitudinally.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty\u2010four children with a history of hospitalization for bronchiolitis before 6 months of age were prospectively studied with impulse oscillometry (IOS) at the mean age of 6.3 years and these preschool IOS results were compared with flow\u2010volume spirometry (FVS) measurements at mean age of 11.4 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The baseline respiratory system resistance at 5\u2009Hz (Rrs5) showed a modest statistically significant correlation with all baseline FVS parameters except FVC. The post\u2010bronchodilator (post\u2010BD) Rrs5 showed a modest statistically significant correlation with post\u2010BD FEV<jats:sub>1<\/jats:sub> and FEV<jats:sub>1<\/jats:sub>\/FVC. The bronchodilator\u2010induced decrease in Rrs5 showed a modest statistically significant correlation with the percent increase in FEV<jats:sub>1<\/jats:sub>. Baseline and post\u2010BD respiratory reactance at 5\u2009Hz (Xrs5) showed a modest statistically significant correlation with baseline and post\u2010BD FVS parameters except post\u2010BD FEV<jats:sub>1<\/jats:sub>\/FVC, respectively, and post\u2010BD Xrs5 showed a strong correlation with post\u2010BD FVC (<jats:italic>\u03c1<\/jats:italic>\u2009=\u20090.61) and post\u2010BD FEV<jats:sub>1<\/jats:sub> (<jats:italic>\u03c1<\/jats:italic>\u2009=\u20090.59). In adjusted linear regression, preschool Xrs5 remained as a statistically significant independent predictor of FVS parameters in adolescence; the one\u2010unit decrease in the <jats:italic>Z<\/jats:italic>\u2010score of preschool post\u2010BD Xrs5 predicted 9.6% lower post\u2010BD FEV<jats:sub>1<\/jats:sub>, 9.3% lower post\u2010BD FVC, and 9.7% lower post\u2010BD MEF<jats:sub>50<\/jats:sub> when expressed as %\u2010predicted parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Persistent post\u2010BD small airway impairment in children with a history of bronchiolitis detected with IOS at preschool age predicted FVS results measured in early adolescence.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.23977","type":"journal-article","created":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T06:22:54Z","timestamp":1519712574000},"page":"552-558","source":"Crossref","is-referenced-by-count":16,"title":["Impulse oscillometry at preschool age is a strong 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