{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T20:10:59Z","timestamp":1776715859017,"version":"3.51.2"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,3,24]],"date-time":"2018-03-24T00:00:00Z","timestamp":1521849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001030","name":"National Heart Foundation of Australia","doi-asserted-by":"publisher","award":["101167"],"award-info":[{"award-number":["101167"]}],"id":[{"id":"10.13039\/501100001030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000190","name":"University of Alberta","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000190","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1035115"],"award-info":[{"award-number":["1035115"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1064163"],"award-info":[{"award-number":["1064163"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Study Objectives<\/jats:title><jats:p>Pulse\u2010oximetry (SpO<jats:sub>2<\/jats:sub>) allows the identification of important clinical physiology. However, summary statistics such as mean values and desaturation incidence do not capture the complexity of the information contained within continuous recordings. The aim of this study was to develop an objective method to quantify important SpO<jats:sub>2<\/jats:sub> characteristics; and assess its utility in healthy infant and preterm neonate cohorts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An algorithm was developed to calculate the desaturation incidence, depth, and duration. These variables are presented using three plots: SpO<jats:sub>2<\/jats:sub> cumulative\u2010frequency relationship; desaturation\u2010depth versus incidence; desaturation\u2010duration versus incidence. This method was applied to two populations who underwent nocturnal pulse\u2010oximetry: (1) thirty\u2010four healthy term infants studied at 2\u2010weeks, 3, 6, 12, and 24\u2010months of age and (2) thirty\u2010seven neonates born &lt;26 weeks and studied at discharge from NICU (37\u201044 weeks post\u2010conceptual age).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The maturation in healthy infants was characterized by reduced desaturation index (27.2\/h vs 3.3\/h at 2\u2010weeks and 24\u2010months, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01), and increased percentage of desaturation events \u22656\u2010s in duration (27.8% vs 43.2% at 2\u2010weeks and 3\u2010months, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). Compared with term\u2010infants, preterm infants had a greater desaturation incidence (54.8\/h vs 27.2\/h, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01), and these desaturations were deeper (52.9% vs 37.6% were \u22656% below baseline, <jats:italic>P\u2009<\/jats:italic>&lt;\u20090.01). The incidence of longer desaturations (\u226514\u2010s) in preterm infants was correlated with healthcare utilization over the first 24\u2010months (<jats:italic>r<\/jats:italic>\u2009=\u20090.63, <jats:italic>P\u2009<\/jats:italic>&lt;\u20090.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This tool allows the objective comparison of extended oximetry recordings between groups and for individuals; and serves as a basis for the development of reference ranges for populations.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.23987","type":"journal-article","created":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T04:36:29Z","timestamp":1521952589000},"page":"645-655","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["A graphical method for comparing nocturnal oxygen saturation profiles in individuals and populations: Application to healthy infants and preterm 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