{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T01:29:09Z","timestamp":1773797349899,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,4,10]],"date-time":"2018-04-10T00:00:00Z","timestamp":1523318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001322","name":"South African Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011512","name":"National Research Foundation","doi-asserted-by":"publisher","award":["105865"],"award-info":[{"award-number":["105865"]}],"id":[{"id":"10.13039\/100011512","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1017641"],"award-info":[{"award-number":["OPP1017641"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Wheezing in early childhood is common and has been identified in high\u2010income countries (HIC) as associated with maternal antenatal or postnatal psychosocial risk factors. However, the association between maternal mental health and childhood wheezing has not been well studied in low and middle\u2010income countries (LMIC), such as South Africa.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 1137 pregnant women over 18 year old, between 20 and 28 weeks\u2019 gestation, and attending either of two catchment area clinics were enrolled in a South African parent study, the Drakenstein Child Health Study (DCHS). Psychosocial risk factors including maternal depression, psychological distress, early adversity, and intimate partner violence (IPV), were measured antenatally and postnatally by validated questionnaires. Two outcomes were evaluated: Presence of wheeze (at least one episode of child wheeze during the first 2 years of life); and recurrent wheeze (two or more episodes of wheezing in a 12\u2010month period). Logistic regression was used to investigate the association between antenatal or postnatal psychosocial risk factors and child wheeze, adjusting for clinical and socio\u2010demographic covariates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Postnatal psychological distress and IPV were associated with both presence of wheeze (adjusted OR\u2009=\u20092.09, 95%CI: 1.16\u20103.77 and 1.63, 95%CI: 1.13\u20102.34, respectively), and recurrent child wheeze (adjusted OR\u2009=\u20092.26, 95%CI: 1.06\u20104.81 and 2.20, 95%CI: 1.35\u20103.61, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Maternal postnatal psychological distress and IPV were associated with wheezing in early childhood. Thus, screening and treatment programs to address maternal psychosocial risk factors may be potential strategies to reduce the burden of childhood wheeze in LMICs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.24008","type":"journal-article","created":{"date-parts":[[2018,4,10]],"date-time":"2018-04-10T23:36:31Z","timestamp":1523403391000},"page":"741-754","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Associations between maternal mental health and early child wheezing in a South African birth cohort"],"prefix":"10.1002","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7601-2994","authenticated-orcid":false,"given":"Rae P.","family":"MacGinty","sequence":"first","affiliation":[{"name":"Department of Pediatrics and Child Health Red Cross War Memorial Children's Hospital and Medical Research Council Unit on Child and Adolescent Health University of Cape Town Cape Town South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maia","family":"Lesosky","sequence":"additional","affiliation":[{"name":"Division of Epidemiology and Biostatistics School of Public Health and Family Medicine University of Cape Town Cape Town South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Whitney","family":"Barnett","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Child Health Red Cross War Memorial Children's Hospital and Medical Research Council Unit on Child and Adolescent Health University of Cape Town Cape Town South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan J.","family":"Stein","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Mental Health Medical Research Council Unit on Anxiety and Stress Disorders and Medical Research Council Unit on Risk and Resilience in Mental Disorders University of Cape Town Cape Town South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather J.","family":"Zar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Child Health Red Cross War Memorial Children's Hospital and Medical Research Council Unit on Child and Adolescent Health University of Cape Town Cape Town South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,4,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199501193320301"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.12.001"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-3955(16)38440-1"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2011.03.004"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201602-0272OC"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201201-0162OC"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.108.4.e69"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12837"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200703-381OC"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0890334405280947"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.11.010"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0121459"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.165.3.2102016"},{"key":"e_1_2_7_15_1","article-title":"Investigating the early\u2010life determinants of illness in Africa: the Drakenstein Child Health Study","author":"Zar HJ","year":"2014","journal-title":"Thorax"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2015.03.016"},{"key":"e_1_2_7_17_1","first-page":"11","article-title":"Maternal participant experience in a South African birth cohort study enrolling healthy pregnant women and their infants","author":"Barnett W","year":"2016","journal-title":"Philos Ethics Humanit Med"},{"key":"e_1_2_7_18_1","first-page":"e009111","article-title":"Incidence of childhood pneumonia: facility\u2010based surveillance estimate compared to measured incidence in a South African birth cohort study","volume":"5","author":"le Roux DM","year":"2015","journal-title":"BMJ"},{"key":"e_1_2_7_19_1","unstructured":"World Health Organization. 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