{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:53:21Z","timestamp":1786978401431,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,4,10]],"date-time":"2018-04-10T00:00:00Z","timestamp":1523318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004344","name":"Stichting Astma Bestrijding","doi-asserted-by":"publisher","award":["2013\/016"],"award-info":[{"award-number":["2013\/016"]}],"id":[{"id":"10.13039\/501100004344","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>The number of children requiring pediatric intensive care unit (PICU) admission for severe acute asthma (SAA) around the world has increased.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We investigated whether this trend in SAA PICU admissions is present in the Netherlands.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A multicenter retrospective cohort study across all tertiary care PICUs in the Netherlands. Inclusion criteria were children (2\u201018 years) hospitalized for SAA between 2003 and 2013. Data included demographic data, asthma diagnosis, treatment, and mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the 11\u2010year study period 590 children (660 admissions) were admitted to a PICU with a threefold increase in the number of admissions per year over time. The severity of SAA seemed unchanged, based on the first blood gas, length of stay and mortality rate (0.6%). More children received highflow nasal cannula (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) and fewer children needed invasive ventilation (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). In 58% of the patients the maximal intravenous (IV) salbutamol infusion rate during PICU admission was 1\u2009mcg\/kg\/min. However, the number of patients treated with IV salbutamol in the referring hospitals increased significantly over time (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.005). The proportion of steroid\u2010na\u00efve patients increased from 35% to 54% (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.004), with a significant increase in both age groups (2\u20104 years [\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.026] and 5\u201017 years [\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.036]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The number of children requiring PICU admission for SAA in the Netherlands has increased. We speculate that this threefold increase is explained by an increasing number of steroid\u2010na\u00efve children, in conjunction with a lowered threshold for PICU admission, possibly caused by earlier use of salbutamol IV in the referring hospitals.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.24009","type":"journal-article","created":{"date-parts":[[2018,4,10]],"date-time":"2018-04-10T19:35:46Z","timestamp":1523388946000},"page":"857-865","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Children with severe acute asthma admitted to Dutch PICUs: A changing landscape"],"prefix":"10.1002","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9870-2067","authenticated-orcid":false,"given":"Shelley A.","family":"Boeschoten","sequence":"first","affiliation":[{"name":"Department of Pediatric Intensive Care, Erasmus Medical Centre Sophia's Children Hospital Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne M. P.","family":"Buysse","sequence":"additional","affiliation":[{"name":"Department of Pediatric Intensive Care, Erasmus Medical Centre Sophia's Children Hospital Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J. F. M.","family":"Merkus","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Respiratory Medicine Radboudumc Amalia Children's Hospital Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob M. C.","family":"van Wijngaarden","sequence":"additional","affiliation":[{"name":"Department of Pediatric Intensive Care, Erasmus Medical Centre Sophia's Children Hospital Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabien G. J.","family":"Heisterkamp","sequence":"additional","affiliation":[{"name":"Department of Pediatric Intensive Care, Academic Medical Centre Emma's Children Hospital Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan C.","family":"de Jongste","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Erasmus Medical Centre Sophia's Children Hospital Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost","family":"van Rosmalen","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Erasmus MC University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzan C. M.","family":"Cochius\u2010den Otter","sequence":"additional","affiliation":[{"name":"Department of Pediatric Intensive Care, Erasmus Medical Centre Sophia's Children Hospital Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemie L. M.","family":"Boehmer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Maasstad Hospital Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthijs","family":"de Hoog","sequence":"additional","affiliation":[{"name":"Department of Pediatric Intensive Care, Erasmus Medical Centre Sophia's Children Hospital Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of SKIC Dutch collaborative PICU research network","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,10]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"476","article-title":"Global variation in the prevalence and severity of asthma symptoms: phase three of the International Study of Asthma and Allergies in Childhood (ISAAC)","volume":"64","author":"Lai RB CKW","year":"2009","journal-title":"BMJ Open"},{"key":"e_1_2_7_3_1","first-page":"25","article-title":"Astma bij kinderen tot 12 jaar: resultaten van het PIAMA\u2010onderzoek","volume":"2011","author":"Wijga AH","year":"2011","journal-title":"RIVM"},{"key":"e_1_2_7_4_1","first-page":"1","article-title":"Acute severe asthma: recent advances","volume":"13","author":"Kaza V","year":"2007","journal-title":"Curr Opin Pulm Med"},{"key":"e_1_2_7_5_1","unstructured":"Nederlandse Vereniging voor Kindergeneeskunde (NVK) (https:\/\/www.nvk\/0\/richtlijnen\/acuutastma\/acuutastma.pdf)."},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.01325"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/02770903.2011.585411"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/02770900701340445"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.10443"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2015.05.004"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2011.06.025"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-004-2310-9"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2007.00600.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/jsq004"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-3239"},{"key":"e_1_2_7_16_1","doi-asserted-by":"crossref","first-page":"243","DOI":"10.4103\/1817-1737.165302","article-title":"Asthma changes at a pediatric intensive care unit after 10 years: observational study","volume":"10","author":"Al\u2010Eyadhy AA","year":"2015","journal-title":"Ann Thorac Med"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00002108"},{"key":"e_1_2_7_18_1","unstructured":"GINA. 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