{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T01:40:29Z","timestamp":1773279629989,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T00:00:00Z","timestamp":1523836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Magnesium is an adjunctive therapy used in patients with status asthmaticus who do not respond to conventional therapy. The optimal time from initiation of therapy, to determination of response and administration of magnesium has not yet been resolved. Our objective was to determine if magnesium administered in the non\u2010intensive care setting can decrease duration of continuous albuterol and hospital length of stay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective cohort analysis of children ages 2\u201018 years admitted to the pediatric unit on continuous albuterol between January 2014 and December 2015 in a tertiary care children's hospital. Cohorts were matched on respiratory assessment score (RAS) obtained at a similar duration of albuterol therapy and evaluated for the total duration of continuous albuterol, length of stay (LOS), and adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010three patients who received magnesium were matched to 33 patients with the same RAS at a similar duration of continuous albuterol therapy who did not receive magnesium. Those who received magnesium had longer duration on continuous albuterol (34 vs 18\u2009h; <jats:italic>P<\/jats:italic>\u2009=\u20090.001; 95% confidence interval [CI] 4\u201020; effect size 0.41) and longer LOS (72 vs 49\u2009h; <jats:italic>P<\/jats:italic>\u2009=\u20090.037; 95% confidence interval [CI] 1\u201033; effect size 0.26) than those who did not receive magnesium.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Children requiring continuous albuterol for status asthmaticus can be administered magnesium sulfate outside the PICU with a low incidence of adverse events; however, among a RAS matched cohort, those who received magnesium did not experience shorter time on continuous albuterol, or hospital length of stay.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.24013","type":"journal-article","created":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T23:33:58Z","timestamp":1523921638000},"page":"866-871","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The effectiveness of magnesium sulfate for status asthmaticus outside the intensive care setting"],"prefix":"10.1002","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5826-6360","authenticated-orcid":false,"given":"Ryan L.","family":"DeSanti","sequence":"first","affiliation":[{"name":"Department of Pediatric Critical Care University of Wisconsin Madison Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nisha","family":"Agasthya","sequence":"additional","affiliation":[{"name":"Department of Pediatric Critical Care Nemours\/Alfred I DuPont Hospital for Children Wilmington Delaware"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krystal","family":"Hunter","sequence":"additional","affiliation":[{"name":"Cooper Research Institute Cooper University Hospital Camden New Jersey"},{"name":"Cooper Medical School of Rowan University Camden New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed J.","family":"Hussain","sequence":"additional","affiliation":[{"name":"Cooper Medical School of Rowan University Camden New Jersey"},{"name":"Department of Pediatrics Cooper University Hospital Camden New Jersey"},{"name":"Weisman Children's Rehabilitation Hospital Marlton New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,4,16]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"National Asthma Education and Prevention Program Third Expert Panel on the Diagnosis and Management of Asthma. 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