{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T16:35:52Z","timestamp":1771259752012,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,5,23]],"date-time":"2018-05-23T00:00:00Z","timestamp":1527033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"None"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>N\u2010terminal\u2010probrain natriuretic peptide (NT\u2010proBNP) is a marker of hemodynamically significant patent ductus arteriosus (HsPDA) in preterm infants. In this study, we assessed whether NT\u2010proBNP levels could predict the risk of moderate to severe bronchopulmonary dysplasia (BPD) and\/or death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was an observational prospective study of preterm infants with GA\u2009\u226432 weeks. Infants who died within the first 48\u2009h or who had major congenital malformations or incomplete information were excluded. NT\u2010proBNP was determined at 48\u201096\u2009h of life and at 5\u201010 days of life. The predictive capacity of NT\u2010proBNP for the combined outcome of BPD and\/or death was evaluated using receiver operator characteristic (ROC) curves and multivariate regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 125 eligible patients, 110 completed the analysis. Twenty\u2010eight developed BPD (<jats:italic>n<\/jats:italic>\u2009=\u200915) and\/or died (<jats:italic>n<\/jats:italic>\u2009=\u200913). Infants who developed BPD and\/or died had higher NT\u2010proBNP levels \u200b\u200bat 48\u201096\u2009h (26,848\u2009ng\/L, interquartile range [IQR] 7818\u201060,684 vs 3008\u2009ng\/L, IQR 1425\u20109876) and at 5\u201010 days (8849\u2009ng\/L, IQR 3796\u201019,526 vs 1427\u2009ng\/L, IQR 907\u20102889). The NT\u2010proBNP levels at 5\u201010 days, but not at 48\u201096\u2009h, were independently associated with BPD and\/or death after adjustments for HsPDA and other confounders (OR\u2009=\u20093.36; 95%CI: 1.52\u20107.4, <jats:italic>P<\/jats:italic>\u2009=\u20090.006). For the prediction of this result, a cutoff of 3348\u2009ng\/L had a sensitivity and specificity of 82% and 83%, respectively (area under the curve [AUC]\u2009=\u20090.87; 95%CI: 0.79\u20100.95).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The NT\u2010proBNP levels at 5\u201010 days of life may identify preterm infants with an HsPDA who are at high risk of BPD or death and may be useful for individualized preventive and therapeutic strategies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.24053","type":"journal-article","created":{"date-parts":[[2018,5,23]],"date-time":"2018-05-23T11:36:26Z","timestamp":1527075386000},"page":"1073-1081","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["N\u2010terminal\u2010probrain natriuretic peptide as a biomarker of moderate to severe bronchopulmonary dysplasia in preterm infants: A prospective observational 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