{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:53:14Z","timestamp":1791420794781,"version":"4.3.3"},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,6,3]],"date-time":"2018-06-03T00:00:00Z","timestamp":1527984000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100002590","name":"American Lung Association","doi-asserted-by":"publisher","award":["RG\u2010307793"],"award-info":[{"award-number":["RG\u2010307793"]}],"id":[{"id":"10.13039\/100002590","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>A bi\u2010directional relationship exists between asthma and obstructive sleep apnea (OSA) in which presence of one is associated with increased prevalence and severity of the other. Our objective was to determine whether OSA accounted for differences in airway and systemic inflammation in asthmatic children and whether inflammation was associated with asthma control. We hypothesized that greater severity of SDB would correlate with increased upper airway and systemic inflammation and result in reduced asthma control.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Non\u2010obese children aged 4\u201012 years with persistent asthma, with or without OSA were recruited. Asthma control was measured with the Childhood Asthma Control Test. Children underwent polysomnography and blood sampling, and children with OSA underwent clinically indicated adenotonsillectomy. Tonsils and sera were analyzed for 11 cytokines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010seven children (20 with OSA, seven without OSA) participated, mean age 7.9 years, 55.6% female, 92.6% African American. Levels did not differ for any cytokine between children with and without OSA. Lower nadir oxygen saturation was associated with higher levels of tonsil TNF\u2010\u03b1 (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) and IL\u201010 (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05). Higher REM\u2010related apnea\u2010hypopnea index was associated with higher levels of tonsil TNF\u2010\u03b1 (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05). Children with uncontrolled asthma had significantly higher levels of serum IL\u201010, IL\u201013, and TNF\u2010\u03b1, and tonsil TNF\u2010\u03b1 (all\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05) than well\u2010controlled asthmatic children. There was no association between OSA, or any polysomnography variable, and asthma control.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Despite the presence of OSA\u2010associated airway inflammation, and asthma control\u2010associated airway and systemic inflammation, OSA was not related to level of asthma control in this non\u2010obese, largely minority, low income sample.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.24074","type":"journal-article","created":{"date-parts":[[2018,6,4]],"date-time":"2018-06-04T08:25:43Z","timestamp":1528100743000},"page":"1200-1207","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Inflammation and asthma control in children with comorbid obstructive sleep apnea"],"prefix":"10.1002","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7380-2889","authenticated-orcid":false,"given":"Valerie E.","family":"Rogers","sequence":"first","affiliation":[{"name":"School of Nursing University of Maryland Baltimore Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary E.","family":"Bollinger","sequence":"additional","affiliation":[{"name":"School of Medicine University of Maryland Baltimore Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohan E.","family":"Tulapurkar","sequence":"additional","affiliation":[{"name":"School of Medicine University of Maryland Baltimore Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijun","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Nursing University of Maryland Baltimore Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey D.","family":"Hasday","sequence":"additional","affiliation":[{"name":"School of Medicine University of Maryland Baltimore Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin D.","family":"Pereira","sequence":"additional","affiliation":[{"name":"School of Medicine University of Maryland Baltimore Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven M.","family":"Scharf","sequence":"additional","affiliation":[{"name":"School of Medicine University of Maryland Baltimore Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,3]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Asthma Data, Statistics, and Surveillance. Most Recent Asthma Data","year":"2017"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-1672"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.5.9809079"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1353-8292(03)00054-6"},{"key":"e_1_2_8_6_1","first-page":"83","article-title":"Sleep\u2010disordered breathing in children with asthma: a systematic review on the impact of treatment","volume":"9","author":"Sanchez T","year":"2016","journal-title":"J Asthma Allergy"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsc.2011.10.006"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e3181b453e3"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.3236"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000004944"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.2724"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2009.03397.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/147323001103900417"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2015.37"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.25855"},{"key":"e_1_2_8_16_1","volume-title":"Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma: Summary Report","year":"2007"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1389-9457(99)00009-X"},{"key":"e_1_2_8_18_1","first-page":"1","article-title":"Changes in terminology for childhood overweight and obesity","volume":"25","author":"Ogden CL","year":"2010","journal-title":"Natl Health Stat Report"},{"key":"e_1_2_8_19_1","volume-title":"The AASM Manual for the Scoring of Sleep and Associated Events: Rules, Terminology and Technical Specifications. Version 2.2","author":"Berry RB","year":"2015"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.2172"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.168.12.954"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2012.05.011"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.95.08030483"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.03.020"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2013.04.005"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20943"},{"key":"e_1_2_8_28_1","first-page":"102","article-title":"Airway inflammation in patients affected by obstructive sleep apnea","volume":"65","author":"Sabato R","year":"2006","journal-title":"Monaldi Arch Chest Dis"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.08.054"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.22769"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20056"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.22713"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1089\/chi.2016.0176"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwt093"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2013.09.001"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2017.06.018"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-018-1037-7"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.23005"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2010.11.011"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/890706"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2010.11.006"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.24074","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.24074","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T16:23:14Z","timestamp":1694967794000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.24074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,3]]},"references-count":40,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.1002\/ppul.24074"],"URL":"https:\/\/doi.org\/10.1002\/ppul.24074","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,3]]},"assertion":[{"value":"2018-01-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}