{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:16:57Z","timestamp":1792030617001,"version":"4.4.0"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,6,5]],"date-time":"2018-06-05T00:00:00Z","timestamp":1528156800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We aim to verify the diagnostic accuracy of a lung ultrasonography (LUS) score to early predict the need for surfactant therapy in newborns with respiratory distress syndrome (RDS), and to compare it with a chest X\u2010ray score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this prospective diagnostic accuracy study we included all newborns admitted for respiratory distress and initially treated with nasal CPAP. LUS was performed within 2\u2009h from nasal CPAP positioning and in any case before surfactant administration. A chest X\u2010ray was also performed. A LUS score and an X\u2010ray score were used and compared. Ability of the scores to predict surfactant administration was evaluated through ROC analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In our population of 56 newborns with mean gestational age of 31 weeks (SD 3) and mean birth weight of 1442\u2009g (SD 520), LUS score showed higher AUC than X\u2010ray score in early recognition of infants with respiratory distress syndrome requiring surfactant treatment (0.94; 95%CI, 0.89\u20100.98; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001 vs 0.80; 95%CI, 0.74\u20100.86; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). It showed also higher sensitivity (86% vs 82%), higher specificity (88% vs 76%), better positive (83% vs 69%), and negative (91% vs 87%) predictive values.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>LUS is a non\u2010invasive, bedside and reproducible method that could improve the management of neonatal respiratory distress. It is accurate and reliable to early identify patients who will need treatment with surfactant allowing both an early treatment and a reduction of radiation exposure.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.24076","type":"journal-article","created":{"date-parts":[[2018,6,5]],"date-time":"2018-06-05T13:45:14Z","timestamp":1528206314000},"page":"1231-1236","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":77,"title":["Lung ultrasonography score versus chest X\u2010ray score to predict surfactant administration in newborns with respiratory distress syndrome"],"prefix":"10.1002","volume":"53","author":[{"given":"Alessandro","family":"Perri","sequence":"first","affiliation":[{"name":"Department of Neonatology Catholic University of the Sacred Heart Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9590-7948","authenticated-orcid":false,"given":"Riccardo","family":"Riccardi","sequence":"additional","affiliation":[{"name":"Department of Neonatology Catholic University of the Sacred Heart Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossella","family":"Iannotta","sequence":"additional","affiliation":[{"name":"Department of Neonatology Catholic University of the Sacred Heart Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico V.","family":"Di Molfetta","sequence":"additional","affiliation":[{"name":"Department of Radiology Catholic University of the Sacred Heart Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Arena","sequence":"additional","affiliation":[{"name":"Department of Neonatology Catholic University of the Sacred Heart Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3121-9569","authenticated-orcid":false,"given":"Giovanni","family":"Vento","sequence":"additional","affiliation":[{"name":"Department of Neonatology Catholic University of the Sacred Heart Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Zecca","sequence":"additional","affiliation":[{"name":"Department of Neonatology Catholic University of the Sacred Heart Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-2959"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.1015"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/000992289703600506"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/neo.15-1-e2"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000113059"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000097454"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-3782(14)50011-4"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2014-206803"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2016.04.018"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-012-2513-4"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000448985"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-3443"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000445932"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc11865"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-3924"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201003-0369OC"},{"key":"e_1_2_7_18_1","first-page":"1282","article-title":"Lung ultrasound in the ICU: from diagnostic instrument to respiratory monitoring tool","volume":"78","author":"Via G","year":"2012","journal-title":"Minerva Anestesiol"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-016-2744-4"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000358227"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2016.02.643"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2015.1797"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpm.2010.096"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-2800"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEJ.0b013e3283101685"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.2174\/157339612802139389"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000005826"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.13-2852"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.14-1306"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2017-312818"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2013.96"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.24076","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.24076","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T20:23:21Z","timestamp":1694982201000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.24076"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,5]]},"references-count":30,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.1002\/ppul.24076"],"URL":"https:\/\/doi.org\/10.1002\/ppul.24076","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,5]]},"assertion":[{"value":"2018-03-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}