{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T15:59:46Z","timestamp":1779379186345,"version":"3.53.1"},"reference-count":38,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,6,25]],"date-time":"2018-06-25T00:00:00Z","timestamp":1529884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Novartis de Colombia S.A."}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Some studies, mainly in Europe, have shown a low level of sensitization to house dust mite (HDM) allergens at high altitude (HA). Differently, some others in tropical countries have shown a higher level. The aim of this study was to evaluate allergens sensitization, including HDM, in children with severe asthma (SA), residents at HA in a tropical middle\u2010income developing country.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Observational, analytical, cross\u2010sectional study in children aged 6\u201015 years old with SA at HA (2640\u2009m). Skin prick tests (SPT), serum IgE, exhaled fraction of nitric oxide (FE<jats:sub>NO<\/jats:sub>), spirometry, and asthma questionnaire (ACT) were performed. Associations were explored by Pearson or Spearman coefficients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 61 children. Most patients were male (61.3%), median age: 10 years (Interquartile range [IQR]: 8\u201012), median BMI: 17\u2009kg\/m<jats:sup>2<\/jats:sup> (IQR: 16\u201020); Median of positive SPT: 2 (IQR: 2\u20103). At least one SPT was positive in 88.7% of patients and 87.9% were positive for at least one HDM. Serum IgE: 348\u2009UI\/mL (IQR: 154\u2010760) and FE<jats:sub>NO<\/jats:sub>: 22 ppb (IQR: 9\u201041). Prebronchodilator values were (% predicted): FVC: 109.7% (\u00b115.5%), FEV<jats:sub>1<\/jats:sub>: 98.4% (\u00b116.3); FEV<jats:sub>1<\/jats:sub>\/FVC: 82% (\u00b18%). SPT were inversely correlated with the FEV<jats:sub>1<\/jats:sub>\/FVC (Rho: \u22120.34; 95% CI: \u22120.55 a \u22120.09; <jats:italic>P<\/jats:italic>\u2009=\u20090.008).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These children with SA living at HA in a tropical middle\u2010income developing country have a high prevalence of HDM sensitization. One explanation for this might be that tropical conditions, such as temperature and humidity, could modify the effect of the altitude on asthma.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.24079","type":"journal-article","created":{"date-parts":[[2018,6,25]],"date-time":"2018-06-25T11:10:58Z","timestamp":1529925058000},"page":"1356-1361","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["High prevalence of house dust mite sensitization in children with severe asthma living at high altitude in a tropical country"],"prefix":"10.1002","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8474-5725","authenticated-orcid":false,"given":"Elida","family":"Duenas\u2010Meza","sequence":"first","affiliation":[{"name":"Pediatric Pulmonology Section Fundaci\u00f3n Neumol\u00f3gica Colombiana Bogot\u00e1 Colombia"},{"name":"Research Department Fundaci\u00f3n Neumol\u00f3gica Colombiana Bogot\u00e1 Colombia"},{"name":"Universidad de La Sabana Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0004-8955","authenticated-orcid":false,"given":"Carlos A.","family":"Torres\u2010Duque","sequence":"additional","affiliation":[{"name":"Research Department Fundaci\u00f3n Neumol\u00f3gica Colombiana Bogot\u00e1 Colombia"},{"name":"Universidad de La Sabana Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliana","family":"Correa\u2010Vera","sequence":"additional","affiliation":[{"name":"Research Department Fundaci\u00f3n Neumol\u00f3gica Colombiana Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Su\u00e1rez","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology Section Fundaci\u00f3n Neumol\u00f3gica Colombiana Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catalina","family":"V\u00e1squez","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology Section Fundaci\u00f3n Neumol\u00f3gica Colombiana Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Jurado","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology Section Fundaci\u00f3n Neumol\u00f3gica Colombiana Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"del Socorro Medina","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology Section Fundaci\u00f3n Neumol\u00f3gica Colombiana Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Bar\u00f3n","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology Section Fundaci\u00f3n Neumol\u00f3gica Colombiana Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda J.","family":"Pareja\u2010Zabala","sequence":"additional","affiliation":[{"name":"Research Department Fundaci\u00f3n Neumol\u00f3gica Colombiana Bogot\u00e1 Colombia"},{"name":"Universidad de La Sabana Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7574-7913","authenticated-orcid":false,"given":"Luis F.","family":"Giraldo\u2010Cadavid","sequence":"additional","affiliation":[{"name":"Research Department Fundaci\u00f3n Neumol\u00f3gica Colombiana Bogot\u00e1 Colombia"},{"name":"Universidad de La Sabana Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00202013"},{"key":"e_1_2_6_3_1","unstructured":"(GINA) GIFA. 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