{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T01:51:17Z","timestamp":1772070677850,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,7,12]],"date-time":"2018-07-12T00:00:00Z","timestamp":1531353600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare short\u2010term application of nasal high\u2010frequency oscillatory ventilation (nHFOV) with nasal continuous positive airway pressure (nCPAP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Working Hypothesis<\/jats:title><jats:p>nHFOV improves CO<jats:sub>2<\/jats:sub> removal with respect to nCPAP in preterm infants needing noninvasive respiratory support and persistent oxygen supply after the first 72\u2009h of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Multicenter non\u2010blinded prospective randomized crossover study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patient Selection<\/jats:title><jats:p>Thirty premature infants from eight tertiary neonatal intensive care units, of mean\u2009\u00b1\u2009SD 26.4\u2009\u00b1\u20091.8 weeks of gestational age and 921\u2009\u00b1\u2009177\u2009g of birth weight.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>Infants were randomly allocated in a 1:1 ratio to receive a starting treatment mode of either nCPAP or nHFOV delivered by the ventilator CNO (Medin, Germany), using short binasal prongs of appropriate size. A crossover design with four 1\u2010h treatment periods was used, such that each infant received both treatments twice. The primary outcome was the mean transcutaneous partial pressure of CO<jats:sub>2<\/jats:sub> (TcCO<jats:sub>2<\/jats:sub>) value during the 2\u2010h cumulative period of nHFOV compared with the 2\u2010h cumulative period of nCPAP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significantly lower TcCO<jats:sub>2<\/jats:sub> values were observed during nHFOV compared with nCPAP: 47.5\u2009\u00b1\u20097.6 versus 49.9\u2009\u00b1\u20097.2\u2009mmHg, respectively, <jats:italic>P<\/jats:italic>\u2009=\u20090.0007. A different TcCO<jats:sub>2<\/jats:sub> behavior was found according to the random sequence: in patients starting on nCPAP, TcCO<jats:sub>2<\/jats:sub> significantly decreased from 50.0\u2009\u00b1\u20098.0 to 46.6\u2009\u00b1\u20097.5\u2009mmHg during nHFOV (<jats:italic>P<\/jats:italic>\u2009=\u20090.001). In patients starting on nHFOV, TcCO<jats:sub>2<\/jats:sub> slightly increased from 48.5\u2009\u00b1\u20097.8 to 49.9\u2009\u00b1\u20096.7\u2009mmHg during nCPAP (<jats:italic>P<\/jats:italic>\u2009=\u20090.13).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>nHFOV delivered through nasal prongs is more effective than nCPAP in improving the elimination of CO<jats:sub>2<\/jats:sub>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.24120","type":"journal-article","created":{"date-parts":[[2018,7,12]],"date-time":"2018-07-12T12:57:46Z","timestamp":1531400266000},"page":"1245-1251","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Nasal high\u2010frequency oscillatory ventilation and CO<sub>2<\/sub> removal: A randomized controlled crossover trial"],"prefix":"10.1002","volume":"53","author":[{"given":"Roberto","family":"Bottino","sequence":"first","affiliation":[{"name":"Department for the Protection of Women's Health and the Nascent Life Division of Neonatology Fondazione Poliambulanza Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Pontiggia","sequence":"additional","affiliation":[{"name":"Department for the Protection of Women's Health and the Nascent Life Division of Neonatology Fondazione Poliambulanza Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cinzia","family":"Ricci","sequence":"additional","affiliation":[{"name":"Department for the Protection of Women's Health and the Nascent Life, Child and Adolescent Division of Neonatology Fondazione Policlinico Universitario A. Gemelli Universit\u00e0 Cattolica del Sacro Cuore Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Gambacorta","sequence":"additional","affiliation":[{"name":"Department for the Protection of Women's Health and the Nascent Life, Child and Adolescent Division of Neonatology Fondazione Policlinico Universitario A. Gemelli Universit\u00e0 Cattolica del Sacro Cuore Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Paladini","sequence":"additional","affiliation":[{"name":"Department for the Protection of Women's Health and the Nascent Life, Child and Adolescent Division of Neonatology Fondazione Policlinico Universitario A. Gemelli Universit\u00e0 Cattolica del Sacro Cuore Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimiras","family":"Chijenas","sequence":"additional","affiliation":[{"name":"Division of Neonatology Vilnius Maternity Hospital Vilnius Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arunas","family":"Liubsys","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Institute of Clinical Medicine Vilnius University Vilnius Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jurate","family":"Navikiene","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Institute of Clinical Medicine Vilnius University Vilnius Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ausrine","family":"Pliauckiene","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Institute of Clinical Medicine Vilnius University Vilnius Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenica","family":"Mercadante","sequence":"additional","affiliation":[{"name":"NICU, Department of Clinical Sciences and Community Health, Fondazione IRCCS C\u00e0 Granda Ospedale Maggiore Policlinico Universit\u00e0 degli Studi di Milano Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariarosa","family":"Colnaghi","sequence":"additional","affiliation":[{"name":"NICU, Department of Clinical Sciences and Community Health, Fondazione IRCCS C\u00e0 Granda Ospedale Maggiore Policlinico Universit\u00e0 degli Studi di Milano Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milena","family":"Tana","sequence":"additional","affiliation":[{"name":"Department for the Protection of Women's Health and the Nascent Life, Child and Adolescent Division of Neonatology Fondazione Policlinico Universitario A. Gemelli Universit\u00e0 Cattolica del Sacro Cuore Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Tirone","sequence":"additional","affiliation":[{"name":"Department for the Protection of Women's Health and the Nascent Life, Child and Adolescent Division of Neonatology Fondazione Policlinico Universitario A. Gemelli Universit\u00e0 Cattolica del Sacro Cuore Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Lio","sequence":"additional","affiliation":[{"name":"Department for the Protection of Women's Health and the Nascent Life, Child and Adolescent Division of Neonatology Fondazione Policlinico Universitario A. Gemelli Universit\u00e0 Cattolica del Sacro Cuore Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Aurilia","sequence":"additional","affiliation":[{"name":"Department for the Protection of Women's Health and the Nascent Life, Child and Adolescent Division of Neonatology Fondazione Policlinico Universitario A. Gemelli Universit\u00e0 Cattolica del Sacro Cuore Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Pastorino","sequence":"additional","affiliation":[{"name":"Section of Hygiene, Institute of Public Health Universit\u00e0 Cattolica del Sacro Cuore Rome Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Velia","family":"Purcaro","sequence":"additional","affiliation":[{"name":"Department for the Protection of Women's Health and the Nascent Life, Child and Adolescent Division of Neonatology Fondazione Policlinico Universitario A. Gemelli Universit\u00e0 Cattolica del Sacro Cuore Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianfranco","family":"Maffei","sequence":"additional","affiliation":[{"name":"Division of Neonatology Azienda Ospedaliero Universitaria Ospedali Riuniti di Foggia Foggia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pio","family":"Liberatore","sequence":"additional","affiliation":[{"name":"Division of Neonatology Azienda Ospedaliero Universitaria Ospedali Riuniti di Foggia Foggia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Consigli","sequence":"additional","affiliation":[{"name":"Division of Neonatology Ospedale San Pietro FBF Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Haass","sequence":"additional","affiliation":[{"name":"Division of Neonatology Ospedale San Pietro FBF Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluca","family":"Lista","sequence":"additional","affiliation":[{"name":"Department of Pediatrics NICU Ospedale dei Bambini V. 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