{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:24:57Z","timestamp":1790364297362,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,12,14]],"date-time":"2018-12-14T00:00:00Z","timestamp":1544745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["HONG16A0"],"award-info":[{"award-number":["HONG16A0"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Prevalence of fungi has been rising in the cystic fibrosis (CF) population. <jats:italic>Scedosporium<\/jats:italic> species (spp) is the second most common mold seen in the CF respiratory tract. However, the characteristics associated with <jats:italic>Scedosporium<\/jats:italic> isolation and its clinical implications are poorly understood. The goal of this study was to determine clinical factors associated with <jats:italic>Scedosporium<\/jats:italic> spp to better understand the mechanisms that may contribute to the emergence of filamentous fungi in CF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective cohort study of subjects followed in the CF Foundation Patient Registry between January 1, 2010 and December 31, 2012. Patients under 6 years of age, history of solid organ transplantation, and insufficient respiratory culture data were excluded. We used a multivariable logistic regression model to determine demographic data and baseline disease characteristics, medications and co\u2010infections associated with <jats:italic>Scedosporium<\/jats:italic> spp recovery in CF sputum.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 19\u2009023 subjects, prevalence of <jats:italic>Scedosporium<\/jats:italic> spp was 615 (3.2%). Older age (odds ratio [OR] 1.16, 95% confidence interval [CI] 1.07, 1.26) and white race (OR 1.69, 95% CI 1.09, 2.63) were the demographic factors associated with <jats:italic>Scedosporium<\/jats:italic> spp isolation. Inhaled antibiotic use had a significant association with <jats:italic>Scedosporium<\/jats:italic> isolation (OR 2.01, 95% CI 1.61, 2.52). For every additional course of intravenous antibiotics, the odds of <jats:italic>Scedosporium<\/jats:italic> isolation increased by 8% (OR 1.08, 95% CI 1.03, 1.14).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The association between inhaled antibiotics and <jats:italic>Scedosporium<\/jats:italic> informs us that chronic inhaled antibiotics may be playing a role in <jats:italic>Scedosporium<\/jats:italic> isolation. Further investigation to better characterize this relationship is necessary.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.24210","type":"journal-article","created":{"date-parts":[[2018,12,14]],"date-time":"2018-12-14T10:28:37Z","timestamp":1544783317000},"page":"133-140","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Inhaled antibiotic use is associated with <i>Scedosporium\/Lomentospora<\/i> species isolation in cystic fibrosis"],"prefix":"10.1002","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9321-8399","authenticated-orcid":false,"given":"Gina","family":"Hong","sequence":"first","affiliation":[{"name":"Department of Medicine, Pulmonary, Allergy, and Critical Care Division University of Pennsylvania Perelman School of Medicine Philadelphia 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