{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:52:20Z","timestamp":1747151540774,"version":"3.40.5"},"reference-count":55,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T00:00:00Z","timestamp":1548115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Surfactant protein D (SP\u2010D) is considered a candidate biomarker for lung integrity and for disease progression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>We determined the level of SP\u2010D in children and adolescents with SCD and assessed its possible relation to pulmonary complications and lung function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Serum SP\u2010D levels were assessed in 50 SCD patients compared with 30 healthy controls. High\u2010resolution computerized tomography (HRCT) of the chest was done. Forced vital capacity (FVC), forced expiratory volume in 1\u2009s (FEV<jats:sub>1<\/jats:sub>), FEV<jats:sub>1<\/jats:sub>\/FVC% and forced expiratory flow rate during 25\u201075% of expiration (FEF25\u201075%) were determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>SP\u2010D was significantly higher in SCD patients than controls, particularly patients with sickle cell anemia than those with sickle \u03b2\u2010thalassemia. SP\u2010D levels were significantly associated with increasing severity of interstitial lung disease. The highest SP\u2010D levels were observed among patients with restrictive lung disease followed by mixed type then obstructive lung disease. SP\u2010D was positively correlated to HbS and serum ferritin while negatively correlated to duration of hydroxyurea treatment and parameters of pulmonary functions. ROC curve analysis revealed that SP\u2010D cutoff value 720\u2009ng\/mL could significantly detect the presence of abnormal pulmonary function among SCD patients with 82% sensitivity and 88% specificity. Logistic regression analysis showed that SP\u2010D is an independent factor related to abnormal pulmonary function in SCD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>SP\u2010D may be a promising biomarker for screening of SCD patients for risk of later pulmonary complications.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.24257","type":"journal-article","created":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T08:53:18Z","timestamp":1548319998000},"page":"610-619","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Surfactant protein D as a marker for pulmonary complications in pediatric patients with sickle cell disease: Relation to lung function tests"],"prefix":"10.1002","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1834-7427","authenticated-orcid":false,"given":"Azza A.","family":"Tantawy","sequence":"first","affiliation":[{"name":"Faculty of Medicine Pediatrics Department Ain Shams University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amira A.","family":"Adly","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Pediatrics Department Ain Shams University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatma S. 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