{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:23:33Z","timestamp":1791498213199,"version":"4.3.4"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T00:00:00Z","timestamp":1548115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["BONUS11KO"],"award-info":[{"award-number":["BONUS11KO"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1DK095738"],"award-info":[{"award-number":["RO1DK095738"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Importance<\/jats:title><jats:p>Treatment recommendations for infants with CF standardize care, but most surveillance or treatment guidance of pulmonary manifestations are consensus\u2010based due to sparse evidence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To report observations about pulmonary correlates of growth and other clinical features in infants with CF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed data from the prospective Baby Observational and Nutrition Study conducted in 28 centers across the US, including clinical features, medications, guardian diaries of respiratory symptoms, oropharyngeal swab cultures and chest radiographs (CXR) collected over the first year of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cough was reported in 84% of infants in the first year. Up to 30% had clinically important cough but only 6.3% had crackles; 16.5% had wheeze. Wisconsin CXR score was above 5 in 23% (normal\u2009=\u20090; maximum score\u2009=\u2009100). <jats:italic>Pseudomonas<\/jats:italic> was recovered from at least one respiratory culture in 24% of infants and was associated with crackles\/wheezes and use of proton pump inhibitors (PPI) (OR\u2009=\u20095.47; 95%CI\u2009=\u20091.36, 21.92; <jats:italic>P<\/jats:italic>\u2009=\u20090.02) or PPI plus histamine\u20102 (H2) blocker (OR\u2009=\u20098.2; 95%CI\u2009=\u20092.41, 27.93; <jats:italic>P<\/jats:italic>\u2009=\u20090.001), but not H2 blocker alone. Hospitalization for respiratory indications occurred in 18% of infants and was associated with crackles\/wheeze and abnormal CXR but not low weight, <jats:italic>Pseudomonas<\/jats:italic> or use of acid blockade.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Cough is common in infants with CF, but few present with crackles\/wheeze or CXR changes. <jats:italic>Pseudomonas<\/jats:italic> is associated with use of PPI or PPI plus H2 blocker, but not with respiratory hospitalization. These observations cannot prove cause and effect but add to our understanding of pulmonary manifestations of CF in infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial Registration<\/jats:title><jats:p>United States <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials.Gov\">ClinicalTrials.Gov<\/jats:ext-link> registry NCT01424696 (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">clinicaltrials.gov<\/jats:ext-link>).<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.24261","type":"journal-article","created":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T08:58:54Z","timestamp":1548320334000},"page":"581-586","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Pulmonary findings in infants with cystic fibrosis during the first year of life: Results from the Baby Observational and Nutrition Study (BONUS) cohort study"],"prefix":"10.1002","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5467-5423","authenticated-orcid":false,"given":"Danielle","family":"Goetz","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Pulmonology University at Buffalo Buffalo New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2021-7990","authenticated-orcid":false,"given":"Benjamin T.","family":"Kopp","sequence":"additional","affiliation":[{"name":"Nationwide Children's Hospital Division of Pulmonary Medicine Columbus Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Salvator","sequence":"additional","affiliation":[{"name":"Biostatistics Core Research Institute at Nationwide Children's Hospital Columbus Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Moore\u2010Clingenpeel","sequence":"additional","affiliation":[{"name":"Biostatistics Core Research Institute at Nationwide Children's Hospital Columbus Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"McCoy","sequence":"additional","affiliation":[{"name":"Nationwide Children's Hospital Division of Pulmonary Medicine Columbus Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel H.","family":"Leung","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine, Department of Pediatrics Division of Gastroenterology, Hepatology, and Nutrition Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Kloster","sequence":"additional","affiliation":[{"name":"Cystic Fibrosis Foundation Therapeutics Development Network Coordinating Center Seattle Children's Research Institute Seattle Washington"},{"name":"Department of Pediatrics, Division of Pulmonary and Sleep Medicine University of Washington Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonnie R.","family":"Ramsey","sequence":"additional","affiliation":[{"name":"Cystic Fibrosis Foundation Therapeutics Development Network Coordinating Center Seattle Children's Research Institute Seattle Washington"},{"name":"Department of Pediatrics, Division of Pulmonary and Sleep Medicine University of Washington Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonya H.","family":"Heltshe","sequence":"additional","affiliation":[{"name":"Cystic Fibrosis Foundation Therapeutics Development Network Coordinating Center Seattle Children's Research Institute Seattle Washington"},{"name":"Department of Pediatrics, Division of Pulmonary and Sleep Medicine University of Washington Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Drucy","family":"Borowitz","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Pulmonology University at Buffalo Buffalo New York"},{"name":"Cystic Fibrosis Foundation Bethesda 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