{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T15:46:02Z","timestamp":1769183162066,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,1,27]],"date-time":"2019-01-27T00:00:00Z","timestamp":1548547200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess oxygen diffusion at 36 weeks\u2019 post\u2010menstrual age in preterm infants by means of the non\u2010invasive oxygen saturation\/fraction of inspired oxygen ratio (36w\u2010SFR) and to identify factors associated with 36w\u2010SFR \u2212 ie, gestational age (GA) and early respiratory disease patterns (ERP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective analysis of prospectively collected data. Setting: Neonatal Intensive Care Unit. Patients: 1005 preterm infants born below 32 weeks\u2019 GA. Interventions: 36w\u2010SFR was the mean of SFR values over 24\u2009h on the day infants reached 36 weeks\u2019 PMA. Main outcome measures: 36w\u2010SFR. Statistics: descriptive statistics, univariate, and multivariate analysis to study associations of 36w\u2010SFR, including GA and ERP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>36w\u2010SFR was significantly different between infants with and without bronchopulmonary dysplasia (BPD) (371 vs 467, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), and according to ERP (LowFIO2 466, pulmonary improvement\u2010PI 460, pulmonary deterioration\u2010PD 405, early persistent pulmonary deterioration\u2010EPPD 344, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Significant differences were found either in BPD and in non\u2010BPD patients according to ERP (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Patients without BPD had significant differences in 36w\u2010SFR according to GA (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), while infants with BPD and increasing GA at birth had a non\u2010significant trend for increased 36w\u2010SFR (<jats:italic>P<\/jats:italic>\u2009=\u20090.621). Factors associated with 36w\u2010SFR were GA, being small for GA, sepsis, human milk feeding, and ERP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Preterm infants without BPD had a spectrum of oxygen diffusion impairment that was inversely associated with GA at birth. Infants with different patterns of ERP had significant differences in 36w\u2010SFR.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.24265","type":"journal-article","created":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T05:54:04Z","timestamp":1548654844000},"page":"637-643","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Oxygen saturation\/FIO2 ratio at 36 weeks\u2019 PMA in 1005 preterm infants: Effect of gestational age and early respiratory disease patterns"],"prefix":"10.1002","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5304-1485","authenticated-orcid":false,"given":"Stefano","family":"Nobile","sequence":"first","affiliation":[{"name":"Department of Mother and Child Health Salesi Children's Hospital Ancona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Marchionni","sequence":"additional","affiliation":[{"name":"Department of Industrial Engineering 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