{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T20:08:04Z","timestamp":1787861284049,"version":"build-2784847793"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T00:00:00Z","timestamp":1548720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"MRC","award":["MR\/M022552\/1"],"award-info":[{"award-number":["MR\/M022552\/1"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Decreased lung function is common in preterm\u2010born survivors. Increased fractional exhaled nitric oxide (FeNO) appears to be a reliable test for eosinophillic airway inflammation especially in asthma. We, systematically, reviewed the literature to compare FeNO levels in preterm\u2010born children and adults who did or did not have chronic lung disease of prematurity (CLD) in infancy with term\u2010born controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched eight databases up to February 2018. Studies comparing FeNO levels in preterm\u2010born subjects (&lt;37\u2005weeks\u2019 gestation) in childhood and adulthood with and without (CLD) with term\u2010born subjects were identified and extracted by two reviewers. Data were analysed using Review Manager v5.3.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From 6042 article titles, 183 full articles were screened for inclusion. Nineteen studies met the inclusion criteria. Seventeen studies compared FeNO levels in preterm\u2010 and term\u2010born children and adults; 11 studies (preterm <jats:italic>n<\/jats:italic>\u2009=\u2009640 and term <jats:italic>n<\/jats:italic>\u2009=\u20094005) were included in a meta\u2010analysis. The mean FeNO concentration difference between the preterm\u2010born and term\u2010born group was \u22120.74 (95% CI \u22121.88 to 0.41) ppb. For the six studies reporting data on CLD (preterm <jats:italic>n<\/jats:italic>\u2009=\u2009204 and term <jats:italic>n<\/jats:italic>\u2009=\u2009211) the mean difference for FeNO levels was \u22122.82 (95% CI \u22125.87 to 0.22) ppb between the preterm\u2010born CLD and term\u2010born groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our data suggest that preterm born children with and without CLD have similar FeNO levels to term\u2010born children suggesting an alternative mechanism to eosinophilic inflammation for symptoms of wheezing and airway obstruction observed in preterm\u2010born subjects.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.24270","type":"journal-article","created":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T21:51:55Z","timestamp":1548798715000},"page":"595-601","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Fractional exhaled nitric oxide in preterm\u2010born subjects: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7789-2057","authenticated-orcid":false,"given":"Christopher W.","family":"Course","sequence":"first","affiliation":[{"name":"Welsh Regional Neonatal Intensive Care Unit University Hospital of Wales Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3535-7627","authenticated-orcid":false,"given":"Sailesh","family":"Kotecha","sequence":"additional","affiliation":[{"name":"Department of Child Health School of Medicine Cardiff University Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5640-0300","authenticated-orcid":false,"given":"Sarah J.","family":"Kotecha","sequence":"additional","affiliation":[{"name":"Department of Child Health School of Medicine Cardiff University Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0708473"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60820-4"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.paed.2008.12.010"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra067279"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.82.4.527"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2018.06.001"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.57.7.643"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40733-018-0045-6"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2016-208704"},{"key":"e_1_2_10_11_1","first-page":"CD011439","article-title":"Exhaled nitric oxide levels to guide treatment for children with asthma","volume":"11","author":"Petsky HL","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12957"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2012-203079"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000371539"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001596"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0155695"},{"key":"e_1_2_10_17_1","unstructured":"Review Manager (RevMan) [Computer program]. 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