{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T21:39:00Z","timestamp":1771969140248,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,3,18]],"date-time":"2019-03-18T00:00:00Z","timestamp":1552867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The ratio of ventilation to blood flow is an important determinant for regional gas exchange in the lung and hypoxemia is one of the clinical hallmarks in infants with bronchopulmonary dysplasia (BPD). We have previously demonstrated ventilation\/perfusion ratio (V\/Q) abnormalities in infants with BPD at 36 week\u015b postconceptional age. The status of V\/Q matching in older children with a history of BPD in infancy is unknown. In this study, we examined if 10\u2010year\u2010old children with a history of BPD had V\/Q impairments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Three\u2010dimensional V\/Q\u2010scintigraphy (SPECT) was performed in 26 children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the BPD group, lung volume with mismatch, (V&gt;Q) was larger compared to areas with reverse mismatch (Q&gt;V), 26.2% and 11.8%, respectively, implying that perfusion defects contribute more than ventilation defects in the V\/Q mismatch. Also, the mean fractional distribution of V and Q to V\/Q in children with BPD was reduced compared to healthy children, 31% and 51% compared to 64% and 89%, respectively (<jats:italic>P\u2009<\/jats:italic>&lt;\u20090.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>At 10 years of age children with a history of BPD had ventilation\/perfusion abnormalities, with prominent perfusion defects. These V\/Q abnormalities suggest the presence of residual alveolar\u2010capillary impairment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.24273","type":"journal-article","created":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T22:39:27Z","timestamp":1553035167000},"page":"602-609","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Ten\u2010year\u2010old children with a history of bronchopulmonary dysplasia have regional abnormalities in ventilation perfusion matching"],"prefix":"10.1002","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3928-0754","authenticated-orcid":false,"given":"Malin","family":"Kjellberg","sequence":"first","affiliation":[{"name":"Institute of Women's and Children's Health, Department of Neonatology Karolinska Institute and University Hospital Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Sanchez\u2010Crespo","sequence":"additional","affiliation":[{"name":"Institution of Oncology\u2010Pathology Karolinska Institute Stockholm Sweden"},{"name":"Department of Medical Radiation Physics and Nuclear Medicine Karolinska Univeristy Hospital Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baldvin","family":"Jonsson","sequence":"additional","affiliation":[{"name":"Institute of Women's and Children's Health, Department of Neonatology Karolinska Institute and University Hospital Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,3,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-2959"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.7.2011060"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2017.08.006"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.13672"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2018.01.043"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201503-0552OC"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201711-2287OC"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196702162760701"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199912000-00007"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.22751"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201210-1850OC"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200912-1806OC"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2012-203079"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra067279"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1084-2756(02)00193-8"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.22375"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2017.00088"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-011-1757-5"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.23741"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/MNM.0b013e3282f25905"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-097X.1982.tb00022.x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2006.11.001"},{"key":"e_1_2_8_24_1","first-page":"1289","volume-title":"Ventilation\u2010perfusion relationships. The lung: scientific foundations","author":"West JB","year":"1991"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00092.2003"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-002-0803-8"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200908-1190OC"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201303-0485ED"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201305-124OC"},{"key":"e_1_2_8_30_1","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1542\/peds.63.1.130","article-title":"Preferential distribution of lobar emphysema and atelectasis in bronchopulmonary dysplasia","volume":"63","author":"Moylan FM","year":"1979","journal-title":"Pediatrics"},{"key":"e_1_2_8_31_1","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/s004310050003","article-title":"Persistent acquired lobar overinflation complicating bronchopulmonary dysplasia","volume":"159","author":"Murray C","year":"2000","journal-title":"Eur J Pediatr"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002470050058"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2011.02061.x"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.113.124602"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.24273","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.24273","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ppul.24273","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.24273","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T21:12:31Z","timestamp":1694380351000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.24273"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,18]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["10.1002\/ppul.24273"],"URL":"https:\/\/doi.org\/10.1002\/ppul.24273","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,18]]},"assertion":[{"value":"2018-05-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}