{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T01:51:37Z","timestamp":1772070697888,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,2,18]],"date-time":"2019-02-18T00:00:00Z","timestamp":1550448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["PI14\/00024"],"award-info":[{"award-number":["PI14\/00024"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["PO10174877"],"award-info":[{"award-number":["PO10174877"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Nasal continuous\u2010positive airway pressure (nCPAP) with the INSURE (INtubation\u2010SURfactant\u2010Extubation) or LISA (Less\u2010Invasive Surfactant Administration) procedures are increasingly being chosen as the initial treatment for neonates with surfactant deficiency. Our objective was to compare the effects on cerebral oxygenation of different methods for surfactant administration: INSURE and LISA, using a nasogastric tube (NT) or a LISAcath\u00ae catheter, in spontaneously breathing SF\u2010deficient newborn piglets.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eighteen newborn piglets with SF\u2010deficient lung injury produced by repetitive bronchoalveolar lavages were randomly assigned to INSURE, LISA\u2010NT, or LISAcath\u00ae groups. We assessed pulmonary (gas exchange, lung mechanics, lung histology) and hemodynamic (mean arterial blood pressure, heart rate) changes, cerebral oxygenation (cTOI) and cerebral fractional tissue extraction (cFTOE), with near\u2010infrared spectroscopy, carotid blood flow and brain histology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>SF\u2010deficient piglets developed respiratory distress (F<jats:sub>iO2<\/jats:sub>\u2009=\u20091, pH &lt;7.2, P<jats:sub>aCO2<\/jats:sub> &gt;70\u2009mmHg, P<jats:sub>aO2<\/jats:sub> &lt;70\u2009mmHg, C<jats:sub>dyn<\/jats:sub> &lt;0.5\u2009mL\/cmH<jats:sub>2<\/jats:sub>O\/kg). Rapid improvements in pulmonary status were observed in all surfactant\u2010treated groups without hemodynamic alterations. In the INSURE group, a transient decrease in cTOI occurred during and immediately after surfactant administration, while cTOI only decreased during surfactant administration in the LISA\u2010NT group and did not change significantly in the LISAcath\u00ae group. Brain injury scores were low in all surfactant\u2010treated groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In spontaneously breathing SF\u2010deficient newborn piglets, short\u2010lasting decreases in cerebral oxygenation are associated with surfactant administration by the INSURE method or LISA using an NT, while no cerebral oxygenation changes occurred with LISA using a LISAcath\u00ae. Notably, none of treatments studied seems to have a negative impact on the neonatal brain.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.24277","type":"journal-article","created":{"date-parts":[[2019,2,18]],"date-time":"2019-02-18T12:56:23Z","timestamp":1550494583000},"page":"644-654","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Cerebral oxygenation associated with INSURE versus LISA procedures in surfactant\u2010deficient newborn piglet RDS model"],"prefix":"10.1002","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3855-3327","authenticated-orcid":false,"given":"Carmen","family":"Rey\u2010Santano","sequence":"first","affiliation":[{"name":"Animal Research Unit BioCruces Bizkaia Health Research Institute Barakaldo Bizkaia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria E.","family":"Mielgo","sequence":"additional","affiliation":[{"name":"Animal Research Unit BioCruces Bizkaia Health Research Institute Barakaldo Bizkaia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel A.","family":"Gomez\u2010Solaetxe","sequence":"additional","affiliation":[{"name":"Medical Devices Group University of Basque Country Portugalete Bizkaia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizio","family":"Salomone","sequence":"additional","affiliation":[{"name":"Chiesi Farmaceutici R&amp;D Department Parma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Gastiasoro","sequence":"additional","affiliation":[{"name":"Animal Research Unit BioCruces Bizkaia Health Research Institute Barakaldo Bizkaia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bego\u00f1a","family":"Loureiro","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit Cruces University Hospital Barakaldo Bizkaia 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