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In this group of patients, the lung clearance index seems to be a better marker than FEV<jats:sub>1<\/jats:sub> allowing non\u2010invasive monitoring of changes in small airways. The aim of this study was to investigate the association between the microbiological status and LCI derived from multiple breath washout (MBW) technique as well as FEV<jats:sub>1<\/jats:sub> and FVC in children suffering from cystic fibrosis. Over the 1\u2010year recruitment period, 136 CF patients aged 5\u201018 with: <jats:italic>Staphylococcus aureus<\/jats:italic> (n\u201027), <jats:italic>Pseudomonas aeruginosa<\/jats:italic> (first time (n\u201027), intermittent (n\u20109), and chronic (34) infection), <jats:italic>Aspergillus fumigatus<\/jats:italic> (n\u20106) and without pathogenic flora (n\u201033) were included in the study. Patients had performed a spirometry and MBW test during the visit at outpatient clinic. The study showed that the lung clearance index in patients infected with <jats:italic>Aspergillus fumigatus<\/jats:italic> was significantly higher (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) than in those with normal throat flora. There was also statistically significant differences in the lung clearance index obtained in subjects with chronic <jats:italic>Pseudomonas aeruginosa<\/jats:italic> infection and those with first <jats:italic>Pseudomonas aeruginosa<\/jats:italic> infection (<jats:italic>P\u2009<\/jats:italic>&lt;\u20090.05). Furthermore, significant statistical differences (<jats:italic>P\u2009<\/jats:italic>&lt;\u20090.05) were observed between the groups of patients with chronic <jats:italic>Pseudomonas aeruginosa<\/jats:italic> infection FEV<jats:sub>1\u2009<\/jats:sub>&gt;\u200970% and FEV<jats:sub>1\u2009<\/jats:sub>&lt;\u200970%. In conclusion, LCI was associated with microbiological status of CF patients. Chronic lung infections, especially <jats:italic>Aspergillus fumigatus<\/jats:italic> and <jats:italic>Pseudomonas aeruginosa<\/jats:italic>, were associated with increased LCI. Early eradication of pathological flora positively affects the maintenance of lower LCI.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.24278","type":"journal-article","created":{"date-parts":[[2019,3,6]],"date-time":"2019-03-06T07:30:14Z","timestamp":1551857414000},"page":"729-736","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Change in lung clearance index with microbiological status in children with cystic fibrosis"],"prefix":"10.1002","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6496-8737","authenticated-orcid":false,"given":"Katarzyna","family":"Walicka\u2010Serzysko","sequence":"first","affiliation":[{"name":"Cystic Fibrosis Department Institute of Mother and Child Warsaw Poland"},{"name":"Cystic Fibrosis Centre Pediatric Hospital Dziekan\u00f3w Le\u015bny 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