{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T10:13:23Z","timestamp":1769163203716,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,3,11]],"date-time":"2019-03-11T00:00:00Z","timestamp":1552262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Korea Institute of Child Care and Education"},{"name":"Research of Korea Center for Disease Control and Prevention","award":["2015-ER6601-00"],"award-info":[{"award-number":["2015-ER6601-00"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Although bronchial responsiveness (BR) is usually categorized as normal or hyperresponsive to aid the diagnosis of asthma, it exists on a continuous spectrum, not in a dichotomous manner. We aimed to evaluate the distribution profile of BR in a general\u00a0population of 7\u2010year\u2010olds.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 2015, 7\u2010year\u2010old Korean children from a nationwide birth cohort study visited regional study hospitals for skin prick test, standard spirometry, and bronchial provocation to establish reference values for the general population. Their BR degrees were categorized into five ordered groups: hyperresponsive BRs were classified into group 1 (provocative concentration (PC) of methacholine causing a 20% fall in forced expiratory volume in 1\u2009second [FEV1], PC20 of &lt;4\u2009mg\/mL) and group 2 (PC20 of \u22654\u2009mg\/mL and &lt;16\u2009mg\/mL), and nonresponsive BRs were categorized into group 3 (final FEV1 percentage fall after inhaling 16\u2009mg\/mL of methacholine [FEV1%fall] of &gt;15% and \u226420%), group 4 (FEV1%fall of &gt;10% and \u226415%), and group 5 (FEV1%fall of \u226410%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 559 subjects finished all tests reliably. Groups 1 and 2 comprised 10.0% and 15.7% of the total population, respectively. Groups 3, 4, and 5 comprised 14.7%, 18.4%, and 41.1%, respectively. As the group number increased, the proportion of those with recent wheezing and those with indoor allergen sensitization decreased (<jats:italic>P<\/jats:italic> for trend\u2009=\u20090.001 and <jats:italic>P<\/jats:italic> for trend\u2009&lt;\u20090.001, respectively), and the baseline FEV1\/FVC increased (<jats:italic>P<\/jats:italic> for trend\u2009&lt;\u20090.001)<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>BR of the 7\u2010year\u2010olds in the general population, while showing a wide distribution across phenotypes, is associated with allergic symptoms, negatively correlated with baseline lung function and positively correlated with indoor allergen sensitization.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.24310","type":"journal-article","created":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T04:17:34Z","timestamp":1552364254000},"page":"713-720","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Profiles and characteristics of bronchial responsiveness in general 7\u2010year\u2010old children"],"prefix":"10.1002","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0522-7736","authenticated-orcid":false,"given":"Ji Soo","family":"Park","sequence":"first","affiliation":[{"name":"Department of Pediatrics Seoul National University Hospital, Seoul National University College of Medicine Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0078-8374","authenticated-orcid":false,"given":"Yun Jung","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Seoul National University Hospital, Seoul National University College of Medicine Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7817-8728","authenticated-orcid":false,"given":"Dong In","family":"Suh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Seoul National University Hospital, Seoul National University College of Medicine Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sungsu","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Childhood Asthma Atopy Center, Environmental Health Center, Asan Medical Center University of Ulsan College of Medicine Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young\u2010Ho","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Childhood Asthma Atopy Center, Environmental Health Center, Asan Medical Center University of Ulsan College of Medicine Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"So\u2010Yeon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Childhood Asthma Atopy Center, Environmental Health Center, Asan Medical Center University of Ulsan College of Medicine Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song\u2010I","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hallym University Sacred Heart Hospital Anyang South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji\u2010Won","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Seoul National University Bundang Hospital Seongnam South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gwang Cheon","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National Health Insurance 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