{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:08:23Z","timestamp":1787162903922,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,3,11]],"date-time":"2019-03-11T00:00:00Z","timestamp":1552262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Hamilton Health Sciences Foundation","award":["New Investigator Fund"],"award-info":[{"award-number":["New Investigator Fund"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      We sought to evaluate physiological cardiorespiratory implications of high pressures (&gt;8 cmH\n                      <jats:sub>2<\/jats:sub>\n                      O) on continuous positive airway pressure (CPAP) in preterm neonates.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Fifteen preterm neonates at postmenstrual age \u226532 weeks on CPAP 5 cmH\n                      <jats:sub>2<\/jats:sub>\n                      O were enrolled. Pressures were increased by 2 cmH\n                      <jats:sub>2<\/jats:sub>\n                      O increments until 13 cmH\n                      <jats:sub>2<\/jats:sub>\n                      O. At each increment, cardiac output, electrical diaphragmatic (Edi) activity, and clinical cardiorespiratory parameters were measured. Predefined cut\u2010off values for changes in cardiorespiratory parameters were used as termination criteria. Data, presented as mean (SD), were compared using repeated measures analysis of variance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean GA, age at study, and weight of subjects were 27.4 (2.6) weeks, 58.5 (35.5) days, and 2.3 (0.6) kg, respectively. The median (IQR) time at each CPAP increment was 10 (5, 20) min. Cardiac output (mL\/kg\/min) at 5, 7, 9, 11, and 13 cmH\n                      <jats:sub>2<\/jats:sub>\n                      O were not different at 295 (75), 290 (66), 281 (69), 286 (73), and 292 (58), respectively (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.99). Edi values demonstrated a trend towards decline at 9 cmH\n                      <jats:sub>2<\/jats:sub>\n                      O before rising again. No other cardiorespiratory parameter was different across CPAP levels; no subject met termination criteria.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>High CPAP levels were well tolerated for short durations. Further physiological and clinical research is required on safety\/efficacy in neonates with more severe lung disease, as well as its impact over longer durations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.24312","type":"journal-article","created":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T00:17:28Z","timestamp":1552349848000},"page":"1039-1044","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["High continuous positive airway pressure in neonates: A physiological study"],"prefix":"10.1002","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2609-9240","authenticated-orcid":false,"given":"Amit","family":"Mukerji","sequence":"first","affiliation":[{"name":"Department of Paediatrics McMaster University Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muzafar Gani Abdul","family":"Wahab","sequence":"additional","affiliation":[{"name":"Department of Paediatrics McMaster University Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Souvik","family":"Mitra","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Dalhousie University Halifax Nova Scotia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tapas","family":"Mondal","sequence":"additional","affiliation":[{"name":"Department of Paediatrics McMaster University Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debie","family":"Paterson","sequence":"additional","affiliation":[{"name":"Respiratory Therapy Hamilton Health Sciences Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Beck","sequence":"additional","affiliation":[{"name":"Critical Illness and Injury Research Centre Keenan Research Centre for Biomedical Science of St Michael's Hospital, University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Fusch","sequence":"additional","affiliation":[{"name":"Department of Paediatrics McMaster University Hamilton Ontario Canada"},{"name":"Department of Pediatrics Nuernberg General Hospital, Paracelsus Medical School Nuremberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,11]]},"reference":[{"key":"e_1_2_9_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2015.08.006"},{"key":"e_1_2_9_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23235"},{"key":"e_1_2_9_1_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.9.1124"},{"key":"e_1_2_9_1_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2010.203190"},{"key":"e_1_2_9_1_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2007.118109"},{"key":"e_1_2_9_1_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.13644"},{"key":"e_1_2_9_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2010.12.001"},{"issue":"9","key":"e_1_2_9_1_9_1","first-page":"1209","article-title":"Nasal continuous positive airway pressure (CPAP) for the respiratory care of the newborn infant","volume":"54","author":"Diblasi RM","year":"2009","journal-title":"Respir 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