{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T02:50:30Z","timestamp":1780109430251,"version":"3.54.0"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,3,21]],"date-time":"2019-03-21T00:00:00Z","timestamp":1553126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Rationale<\/jats:title><jats:p>Necrotizing pneumonia is characterized by destruction and liquefaction of the lung tissue and loss of the normal pulmonary parenchymal architecture. During the course of resolution areas of hyperlucency are formed, sometimes with the development of giant lung cysts that can be a field with fluid resembling lung abscess. There is no consensus on the management of these abnormalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the prevalence of giant lung cysts as a complication of necrotizing pneumonia and to report our experience with conservative treatment that achieved complete resolution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Medical chart reviews of all children aged 0 to 18 years hospitalized with necrotizing pneumonia in a single tertiary center from 2015 to 2017, demographic data, and clinical course during and after hospitalization as well as serial chest imaging were collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the study period, 761 children were diagnosed with community\u2010acquired pneumonia, 16 of 761 (2.3%) had necrotizing pneumonia and 6 of 16 (37.5%) with necrotizing pneumonia complicated by a giant lung cyst or lung abscess. All were closely observed and showed complete clinical and radiographic resolution with antibiotic treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Treatment of giant lung cyst formation following necrotizing pneumonia by a conservative approach with prolonged antibiotics results in complete recovery with no need for invasive procedures.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.24321","type":"journal-article","created":{"date-parts":[[2019,3,21]],"date-time":"2019-03-21T18:43:28Z","timestamp":1553193808000},"page":"901-906","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Giant lung cysts following necrotizing pneumonia: Resolution with conservative treatment"],"prefix":"10.1002","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4635-386X","authenticated-orcid":false,"given":"Itai","family":"Gross","sequence":"first","affiliation":[{"name":"Departments of Paediatrics Hadassah\u2010Hebrew University Medical Centre Jerusalem Israel"},{"name":"Departments of Paediatric Emergency Medicine Hadassah\u2010Hebrew University Medical Centre Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oren","family":"Gordon","sequence":"additional","affiliation":[{"name":"Departments of Paediatrics Hadassah\u2010Hebrew University Medical Centre Jerusalem Israel"},{"name":"Departments of Clinical Microbiology and Infectious Diseases Hadassah\u2010Hebrew University Medical Centre Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malena","family":"Cohen\u2010Cymberknoh","sequence":"additional","affiliation":[{"name":"Departments of Paediatrics Hadassah\u2010Hebrew University Medical Centre Jerusalem Israel"},{"name":"Departments of Pediatric Pulmonology Hadassah\u2010Hebrew University Medical Centre Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2565-4185","authenticated-orcid":false,"given":"Joel","family":"Reiter","sequence":"additional","affiliation":[{"name":"Departments of Paediatrics Hadassah\u2010Hebrew University Medical Centre Jerusalem Israel"},{"name":"Departments of Pediatric Pulmonology Hadassah\u2010Hebrew University Medical Centre Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reuven","family":"Tsabari","sequence":"additional","affiliation":[{"name":"Departments of Paediatrics Hadassah\u2010Hebrew University Medical Centre Jerusalem Israel"},{"name":"Departments of Pediatric Pulmonology Hadassah\u2010Hebrew University Medical Centre Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Gileles\u2010Hillel","sequence":"additional","affiliation":[{"name":"Departments of Paediatrics Hadassah\u2010Hebrew University Medical Centre Jerusalem Israel"},{"name":"Departments of Pediatric Pulmonology Hadassah\u2010Hebrew University Medical Centre Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ira","family":"Erlichman","sequence":"additional","affiliation":[{"name":"Departments of Paediatrics Hadassah\u2010Hebrew University Medical Centre Jerusalem Israel"},{"name":"Departments of Neonatology Hadassah\u2010Hebrew University Medical Centre Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avigdor","family":"Hevroni","sequence":"additional","affiliation":[{"name":"Departments of Paediatrics Hadassah\u2010Hebrew University Medical Centre Jerusalem Israel"},{"name":"Departments of Pediatric Pulmonology Hadassah\u2010Hebrew University Medical Centre Jerusalem Israel"},{"name":"Department of Pediatric Pulmonology Kaplan medical Centre Rehovot Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Shoseyov","sequence":"additional","affiliation":[{"name":"Departments of Paediatrics Hadassah\u2010Hebrew University Medical Centre Jerusalem Israel"},{"name":"Departments of Pediatric Pulmonology Hadassah\u2010Hebrew University Medical Centre Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eitan","family":"Kerem","sequence":"additional","affiliation":[{"name":"Departments of Paediatrics Hadassah\u2010Hebrew University Medical Centre Jerusalem Israel"},{"name":"Departments of Pediatric Pulmonology Hadassah\u2010Hebrew University Medical Centre Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,21]]},"reference":[{"key":"e_1_2_7_1_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/586747"},{"key":"e_1_2_7_1_3_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.149.1.8111589"},{"key":"e_1_2_7_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2013.10.001"},{"key":"e_1_2_7_1_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31829be1bb"},{"key":"e_1_2_7_1_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41479-017-0035-0"},{"key":"e_1_2_7_1_7_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00099807"},{"key":"e_1_2_7_1_8_1","first-page":"425","article-title":"Paediatric complicated pneumonia: diagnosis and management of empyema","volume":"16","author":"Chibuk TK","year":"2011","journal-title":"Paediatr Child Health"},{"key":"e_1_2_7_1_9_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1710.101825"},{"key":"e_1_2_7_1_10_1","first-page":"110","article-title":"Clinical characteristics of children with complicated pneumonia caused by Streptococcus pneumoniae","volume":"1","author":"Tan TQ","year":"2002","journal-title":"Pediatr"},{"key":"e_1_2_7_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.23523"},{"key":"e_1_2_7_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2008.10.083"},{"key":"e_1_2_7_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2008.10.018"},{"key":"e_1_2_7_1_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-009-1132-8"},{"key":"e_1_2_7_1_15_1","doi-asserted-by":"publisher","DOI":"10.1086\/650573"},{"key":"e_1_2_7_1_16_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1409.071094"},{"key":"e_1_2_7_1_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-005-1620-5"},{"key":"e_1_2_7_1_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/000992288302200605"},{"key":"e_1_2_7_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2005.03.048"},{"key":"e_1_2_7_1_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199602000-00024"},{"key":"e_1_2_7_1_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-010-2562-0"},{"key":"e_1_2_7_1_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31821b10c3"},{"key":"e_1_2_7_1_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.22534"},{"key":"e_1_2_7_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-5231(05)70168-4"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.24321","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ppul.24321","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.24321","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T13:43:06Z","timestamp":1694353386000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.24321"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,21]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1002\/ppul.24321"],"URL":"https:\/\/doi.org\/10.1002\/ppul.24321","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,21]]},"assertion":[{"value":"2018-10-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}