{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T05:34:32Z","timestamp":1790487272359,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,4,22]],"date-time":"2019-04-22T00:00:00Z","timestamp":1555891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL136927"],"award-info":[{"award-number":["HL136927"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["K12 HD027748\u201023"],"award-info":[{"award-number":["K12 HD027748\u201023"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006501","name":"Cystic Fibrosis Foundation Therapeutics","doi-asserted-by":"publisher","award":["FISCHE16I0"],"award-info":[{"award-number":["FISCHE16I0"]}],"id":[{"id":"10.13039\/100006501","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The cystic fibrosis transmembrane conductance regulator (CFTR) modulators ivacaftor and lumacaftor\/ivacaftor improve the status of existing infections in patients with cystic fibrosis (CF). It is unknown how well these drugs protect patients against incident infections. We hypothesized that CFTR modulator treatment would decrease new infections with <jats:italic>Pseudomonas aeruginosa<\/jats:italic> or <jats:italic>Staphylococcus aureus.<\/jats:italic><\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively studied a single\u2010center cohort of patients with CF during two time periods (2008\u20102011, Era 1) and (2012\u20102015, Era 2) based on the January 2012 approval of ivacaftor. Using Kaplan\u2013Meier analysis, we compared the time to any new infection with <jats:italic>P. aeruginosa<\/jats:italic>, methicillin\u2010resistant \n<jats:italic>S. aureus<\/jats:italic> (MRSA), or methicillin\u2010sensitive \n<jats:italic>S. aureus<\/jats:italic> (MSSA) that was absent during a 2\u2010year baseline. We stratified the analysis based on whether patients received ivacaftor or lumacaftor\/ivacaftor during Era 2. We used the log\u2010rank test and considered \n<jats:italic>P<\/jats:italic> &lt; 0.05 statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For patients receiving ivacaftor or lumacaftor\/ivacaftor in Era 2, there was a statistically significant delay in the time to new bacterial acquisition in Era 2 vs. Era 1 (\n<jats:italic>P<\/jats:italic> = 0.008). For patients who did not receive CFTR modulators, there was a trend toward slower acquisition of new bacterial infections in Era 2 compared to Era 1, but this was not statistically significant (\n<jats:italic>P<\/jats:italic> = 0.10).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients receiving ivacaftor or lumacaftor\/ivacaftor for CF had significantly delayed acquisition of \n<jats:italic>P. aeruginosa<\/jats:italic> and \n<jats:italic>S. aureus<\/jats:italic> after these drugs were released. This method for analyzing incident infections may be useful for future studies of CFTR modulators and bacterial acquisition in CF registry cohorts.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.24341","type":"journal-article","created":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T03:25:02Z","timestamp":1555989902000},"page":"1200-1208","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Pathogen acquisition in patients with cystic fibrosis receiving ivacaftor or lumacaftor\/ivacaftor"],"prefix":"10.1002","volume":"54","author":[{"given":"Sachinkumar B.","family":"Singh","sequence":"first","affiliation":[{"name":"Stead Family Department of Pediatrics University of Iowa Carver College of Medicine Iowa City Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda J.","family":"McLearn\u2010Montz","sequence":"additional","affiliation":[{"name":"Stead Family Department of Pediatrics University of Iowa Carver College of Medicine Iowa City Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Milavetz","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice and Science University of Iowa College of Pharmacy Iowa City Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Levi K.","family":"Gates","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice and Science University of Iowa College of Pharmacy Iowa City Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Fox","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice and Science University of Iowa College of Pharmacy Iowa City Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Logan T.","family":"Murry","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice and Science University of Iowa College of Pharmacy Iowa City Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Sabus","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice and Science University of Iowa College of Pharmacy Iowa City Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry S.","family":"Porterfield","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Iowa Carver College of Medicine Iowa City Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony J.","family":"Fischer","sequence":"additional","affiliation":[{"name":"Stead Family Department of Pediatrics University of Iowa Carver College of Medicine Iowa City 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