{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T18:34:17Z","timestamp":1779302057694,"version":"3.51.4"},"reference-count":42,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T00:00:00Z","timestamp":1557878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We hypothesized that former late preterm (LP) children have abnormal pulmonary physiology parameters, including uneven ventilation distribution, due to premature disruption of normal lung development.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional study evaluating former LP children at the age of 6 to 12 years as compared to term controls. Demographics and child's and family history of asthma\/atopy\/smoking were recorded. The outcome parameters were spirometry, multiple breath washout (MBW) measurement by lung clearance index (LCI), 6\u2010minute walk test (6MWT), symptoms related to asthma and allergy, and Godin Leisure\u2010Time Exercise Questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010nine former LP were compared to 30 term\u2010control children (mean age, 8.2\u2009\u00b1\u20091.7 and 8.8\u2009\u00b1\u20091.8 years, respectively). LP had reduced forced expiratory volume in the first second (FEV1) and forced vital capacity (FVC) compared to term controls (FEV1 1.59\u2009\u00b1\u20090.48 vs 1.80\u2009\u00b1\u20090.39\u2009L, <jats:italic>P\u2009=\u2009<\/jats:italic>0.005 and FVC 1.73\u2009\u00b1\u20090.45 vs 1.99\u2009\u00b1\u20090.49\u2009L, <jats:italic>P\u2009<\/jats:italic>=\u20090.009). There were no differences between the two groups regarding FEV1\/FVC, forced expiratory flow between 25 and 75 (FEF25\u201075), LCI (7.10\u2009\u00b1\u20090.79 vs 6.96\u2009\u00b1\u20090.75, <jats:italic>P\u2009<\/jats:italic>=\u20090.50), 6MW distance, and weekly leisure\u2010activity score. Former LP children had more episodes of wheezing and greater use of asthma medication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This pilot study suggests that LP have lower pulmonary function tests (PFTs) but not ventilation inhomogeneity measured by LCI or functional disturbance. It is unclear if the differences in PFTs are due to late prematurity by itself or are the consequence of maternal and neonatal factors associated with LP. Further larger studies are required to assess the long\u2010term respiratory consequences of LP birth.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.24357","type":"journal-article","created":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T15:29:37Z","timestamp":1557934177000},"page":"1250-1256","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Effect of late preterm birth on lung clearance index and respiratory physiology in school\u2010age children"],"prefix":"10.1002","volume":"54","author":[{"given":"Karin","family":"Yaacoby\u2010Bianu","sequence":"first","affiliation":[{"name":"Pediatric Pulmonary Institute and CF Center Ruth Rappaport Children's Hospital, Rambam Health Care Campus Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moran T.","family":"Plonsky","sequence":"additional","affiliation":[{"name":"Department of Pediatrics B Ruth Rappaport Children's Hospital, Rambam Health Care Campus Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal","family":"Gur","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonary Institute and CF Center Ruth Rappaport Children's Hospital, Rambam Health Care Campus Haifa Israel"},{"name":"Rappaport Faculty of Medicine Technion\u2013Israel Institute of Technology Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0055-5415","authenticated-orcid":false,"given":"Ronen","family":"Bar\u2010Yoseph","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonary Institute and CF Center Ruth Rappaport Children's Hospital, Rambam Health Care Campus Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4538-3098","authenticated-orcid":false,"given":"Amir","family":"Kugelman","sequence":"additional","affiliation":[{"name":"Rappaport Faculty of Medicine Technion\u2013Israel 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