{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T18:08:43Z","timestamp":1774375723057,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,5,17]],"date-time":"2019-05-17T00:00:00Z","timestamp":1558051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>We measured respiratory parameters in children with juvenile idiopathic arthritis (JIA) without clinical signs of respiratory involvement and assessed the influence of methotrexate (MTX) treatment and disease activity on lung function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 49 JIA children and 70 controls lung volumes by spirometry and body plethysmography, and lung diffusion for carbon monoxide (DLCO) with single\u2010breath technique were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>DLCO was significantly different between JIA children and controls (<jats:italic>P<\/jats:italic>\u2009=\u2009.01), whereas no differences were found in flow expiratory volume in 1\u2009second (FEV\n<jats:sub>1<\/jats:sub>), forced vital capacity (FVC), forced expiratory flow at 25% to 75% of FVC (FEF\n<jats:sub>25\u201075<\/jats:sub>), peak expiratory flow, total lung capacity, and residual volume. After dividing study JIA patients according to MTX treatment, a significant difference in DLCO was found among JIA patients treated with MTX and those treated with other drugs and controls (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). A significant difference in DLCO was also found among JIA patients with active disease and those with inactive disease and controls (<jats:italic>P<\/jats:italic>\u2009=\u2009.003). Analysis of covariance showed a weak independent effect of MTX therapy on DLCO after adjusting for sex and height (<jats:italic>P<\/jats:italic>\u2009=\u2009.04). Furthermore, a negative correlation of DLCO with MTX cumulative dose and MTX treatment duration (<jats:italic>r\u2009<\/jats:italic>=\u2009\u2212.58, <jats:italic>P<\/jats:italic>\u2009=\u2009.006; <jats:italic>r\u2009<\/jats:italic>=\u2009\u2212.68, <jats:italic>P<\/jats:italic>\u2009=\u2009.001, respectively) was found, whereas there was no correlation between DLCO and disease activity (<jats:italic>r<\/jats:italic>\u2009=\u2009\u2212.10; <jats:italic>P<\/jats:italic>\u2009=\u2009.51).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In JIA children MTX treatment seems to have a dose\u2010dependent effect on lung function. For this reason in these patients, a regular assessment of lung function, especially with DLCO evaluation, is recommended.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.24360","type":"journal-article","created":{"date-parts":[[2019,5,17]],"date-time":"2019-05-17T09:53:58Z","timestamp":1558086838000},"page":"1242-1249","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Lung function in children with juvenile idiopathic arthritis: A cross\u2010sectional analysis"],"prefix":"10.1002","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6513-3160","authenticated-orcid":false,"given":"Marina","family":"Attanasi","sequence":"first","affiliation":[{"name":"Department of Pediatrics University of Chieti Chieti Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Lucantoni","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Chieti Chieti Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Rapino","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Chieti Chieti Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianna I.","family":"Petrosino","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Chieti Chieti Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela","family":"Marsili","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Chieti Chieti Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgia","family":"Gasparroni","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Chieti Chieti Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7336-4292","authenticated-orcid":false,"given":"Paola","family":"Di Filippo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Chieti Chieti Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabrina","family":"Di Pillo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Chieti Chieti Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Chiarelli","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Chieti Chieti Italy"},{"name":"Center of Excellence on Aging, Department of Pediatrics, \u201cG. 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