{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:31:10Z","timestamp":1777494670736,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,6,18]],"date-time":"2019-06-18T00:00:00Z","timestamp":1560816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Forced expiratory maneuvers are usually difficult in young children. Impulse oscillometry (IOS) requires no active cooperation, is noninvasive, rapid, and easy to perform. This study aimed to compare IOS indexes and forced expiratory volume in 1\u2009second (FEV1) in children for the assessment of bronchial hyperreactivity to methacholine, mannitol, and eucapnic voluntary hyperventilation (EVH).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials<\/jats:title><jats:p>Children aged 3\u201014 years (mean 10.0\u2009\u00b1\u20093.1) with symptoms suggestive of asthma were recruited. IOS measurements were taken before spirometry. Methacholine, mannitol, and EVH tests were performed without a specific order.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 190 children, whose mean age was 10.0\u2009\u00b1\u20093.1 years. Changes in FEV1 correlated significantly with variation in IOS indexes (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05). The indexes with the greatest discriminative capacity were Z5, R5, and X5. Optimal cut\u2010offs were: for methacholine tests, \u226722% in R5, \u226782% for reactance area (AX), and \u226641% for X5; for the mannitol test, \u226718% in R5, \u226740% in AX, and \u226621% for X5. In the EVH test, \u226723% for R5, \u226740% for AX, and a fall of 29% for X5. When using the optimal cut\u2010off points obtained from IOS, the mean number of steps and doses required for methacholine and mannitol tests to induce significant bronchoconstriction were significantly lower compared with spirometry (\n<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The effectiveness of R5, X5, and AX indexes were comparable to FEV1 in assessing bronchial obstruction during bronchial challenge testing. Therefore, IOS may be useful in assessing bronchial obstruction in children who cannot reliably perform spirometric maneuvers during bronchial challenge testing.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.24409","type":"journal-article","created":{"date-parts":[[2019,6,18]],"date-time":"2019-06-18T14:23:55Z","timestamp":1560867835000},"page":"1162-1172","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Comparison of impulse oscillometry and spirometry for detection of airway hyperresponsiveness to methacholine, mannitol, and eucapnic voluntary hyperventilation in children"],"prefix":"10.1002","volume":"54","author":[{"given":"Pamela","family":"Jara\u2010Gutierrez","sequence":"first","affiliation":[{"name":"Departments of Allergy, Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Madrid. Department of Medicine, Universidad Aut\u00f3noma de Madrid. CIBERES Instituto Carlos III"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika","family":"Aguado","sequence":"additional","affiliation":[{"name":"Departments of Allergy, Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Madrid. Department of Medicine, Universidad Aut\u00f3noma de Madrid. CIBERES Instituto Carlos III"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela Garc\u00eda","family":"del Potro","sequence":"additional","affiliation":[{"name":"Departments of Allergy, Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Madrid. Department of Medicine, Universidad Aut\u00f3noma de Madrid. CIBERES Instituto Carlos III"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar","family":"Fernandez\u2010Nieto","sequence":"additional","affiliation":[{"name":"Departments of Allergy, Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Madrid. Department of Medicine, Universidad Aut\u00f3noma de Madrid. CIBERES Instituto Carlos III"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio","family":"Mahillo","sequence":"additional","affiliation":[{"name":"Epidemiology, Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Madrid. Department of Medicine, Universidad Aut\u00f3noma de Madrid. CIBERES Instituto Carlos III"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4689-6837","authenticated-orcid":false,"given":"Joaquin","family":"Sastre","sequence":"additional","affiliation":[{"name":"Departments of Allergy, Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Madrid. Department of Medicine, Universidad Aut\u00f3noma de Madrid. CIBERES Instituto Carlos III"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,6,18]]},"reference":[{"key":"e_1_2_10_1_2_1","unstructured":"Global Initiative for Asthma. Global strategy for asthma management and prevention. Updated 2015.http:\/\/www.ginasthma.org\/local\/uploads\/files\/GINA_Report_2015.pdf2015. Available from:http:\/\/www.ginasthma.org\/local\/uploads\/files\/GINA_Report_2015.pdf"},{"key":"e_1_2_10_1_3_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.123.3_suppl.411S"},{"key":"e_1_2_10_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arbr.2013.07.001"},{"key":"e_1_2_10_1_5_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.13-1875"},{"key":"e_1_2_10_1_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-2113.184875"},{"key":"e_1_2_10_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2010.11.011"},{"key":"e_1_2_10_1_8_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.03.00089403"},{"key":"e_1_2_10_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.10235"},{"key":"e_1_2_10_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2007.08.007"},{"issue":"2","key":"e_1_2_10_1_11_1","first-page":"102","article-title":"Comparative analysis of the bronchodilator response measured by impulse oscillometry (IOS), spirometry and body plethysmography in asthmatic children","volume":"15","author":"Olaguibel JM","year":"2005","journal-title":"J Investig Allergol Clin Immunol"},{"key":"e_1_2_10_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.22551"},{"issue":"7","key":"e_1_2_10_1_13_1","first-page":"575","article-title":"Exercise\u2010induced airway obstruction in young asthmatics measured by impulse oscillometry","volume":"20","author":"Lee JH","year":"2010","journal-title":"J Investig Allergol Clin Immunol"},{"key":"e_1_2_10_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2012.01.007"},{"key":"e_1_2_10_1_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2009.01605.x"},{"key":"e_1_2_10_1_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/02770900903006265"},{"key":"e_1_2_10_1_17_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00034505"},{"key":"e_1_2_10_1_18_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200605-642ST"},{"key":"e_1_2_10_1_19_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.123.4.1276"},{"key":"e_1_2_10_1_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2012.01293.x"},{"key":"e_1_2_10_1_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-012-2475-9"},{"key":"e_1_2_10_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2015.04.022"},{"key":"e_1_2_10_1_23_1","doi-asserted-by":"publisher","DOI":"10.1155\/2005\/297472"},{"key":"e_1_2_10_1_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.21492"},{"key":"e_1_2_10_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2010.10.013"},{"key":"e_1_2_10_1_26_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.97.10102243"},{"key":"e_1_2_10_1_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20805"},{"key":"e_1_2_10_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2005.01.006"},{"key":"e_1_2_10_1_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.22866"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.24409","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.24409","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T19:55:33Z","timestamp":1694289333000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.24409"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,18]]},"references-count":28,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1002\/ppul.24409"],"URL":"https:\/\/doi.org\/10.1002\/ppul.24409","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,18]]},"assertion":[{"value":"2018-09-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}