{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:39:21Z","timestamp":1785458361386,"version":"3.56.0"},"reference-count":42,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,7,8]],"date-time":"2019-07-08T00:00:00Z","timestamp":1562544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the effect of nasal high flow (NHF) cannula on end\u2010expiratory level (EEL), continuous distending pressure (CDP) and regional ventilation distribution in preterm infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A prospective observational clinical study with randomly applied NHF rates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Setting<\/jats:title><jats:p>Preterm infants requiring continuous positive airway pressure (CPAP) respiratory support in a Neonatal Intensive Care Unit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interventions<\/jats:title><jats:p>Infants were measured on randomly applied flow rates at 2, 4, and 6\u2009L\/min of NHF and compared with bubble CPAP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements and Results<\/jats:title><jats:p>Regional ventilation distribution and EEL were measured using electrical impedance tomography (EIT) and respiratory inductance plethysmography (RIP) in 24 preterm infants (31.19\u2009\u00b1\u20091.17 weeks corrected age). Changes in CDP were measured from the esophagus via the nasogastric tube. Physiological variables were also recorded. There were no differences in ventilation distribution, EEL or CDP between CPAP and NHF (<jats:italic>P<\/jats:italic>\u2009&gt;\u2009.05). However, the physiological variables of FiO<jats:sub>2<\/jats:sub> (<jats:italic>P<\/jats:italic>\u2009=\u2009.01) and SpO<jats:sub>2<\/jats:sub>\/FiO<jats:sub>2<\/jats:sub> (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01) were improved on CPAP compared with NHF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>NHF applied in random order with flow rates between 2 to 6\u2009L\/min was equally as good as CPAP in maintaining EEL and ventilation distribution in stable preterm infants. Overall oxygenation was better on CPAP compared to NHF.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.24418","type":"journal-article","created":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T04:42:53Z","timestamp":1562647373000},"page":"1410-1416","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effect of randomization of nasal high flow rate in preterm infants"],"prefix":"10.1002","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4264-9823","authenticated-orcid":false,"given":"Judith L.","family":"Hough","sequence":"first","affiliation":[{"name":"Program for Optimising Outcomes for Mothers and Babies at Risk, Mater Research Institute The University of Queensland  South Brisbane Australia"},{"name":"Discipline of Physiotherapy, School of Allied Health Australian Catholic University  Banyo Australia"},{"name":"Paediatric Critical Care Research Group, Mater Research Institute The University of Queensland  South Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew D.","family":"Shearman","sequence":"additional","affiliation":[{"name":"Program for Optimising Outcomes for Mothers and Babies at Risk, Mater Research Institute The University of Queensland  South Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke","family":"Jardine","sequence":"additional","affiliation":[{"name":"Program for Optimising Outcomes for Mothers and Babies at Risk, Mater Research Institute The University of Queensland  South Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Caldararo","sequence":"additional","affiliation":[{"name":"Program for Optimising Outcomes for Mothers and Babies at Risk, Mater Research Institute The University of Queensland  South Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Schibler","sequence":"additional","affiliation":[{"name":"Paediatric Critical Care Research Group, Mater Research Institute The University of Queensland  South Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,8]]},"reference":[{"key":"e_1_2_6_1_2_1","volume-title":"Report of the Australian and New Zealand Neonatal Network 2016","author":"Chow S.S.W","year":"2018"},{"key":"e_1_2_6_1_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0b013e3282f63953"},{"key":"e_1_2_6_1_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.2011.02070.x"},{"key":"e_1_2_6_1_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211530"},{"key":"e_1_2_6_1_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13049-016-0278-4"},{"key":"e_1_2_6_1_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199611000-00025"},{"key":"e_1_2_6_1_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7210865"},{"key":"e_1_2_6_1_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ANC.0000317258.53330.18"},{"key":"e_1_2_6_1_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211879"},{"issue":"1","key":"e_1_2_6_1_11_1","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1542\/peds.91.1.135","article-title":"Inadvertent administration of positive end\u2010distending pressure during nasal cannula flow","volume":"91","author":"Locke RG","year":"1993","journal-title":"Pediatrics"},{"key":"e_1_2_6_1_12_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.107.5.1081"},{"key":"e_1_2_6_1_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004310100798"},{"key":"e_1_2_6_1_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211828"},{"key":"e_1_2_6_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2008.07.021"},{"key":"e_1_2_6_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2009.04.007"},{"key":"e_1_2_6_1_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.21326"},{"key":"e_1_2_6_1_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1300071"},{"key":"e_1_2_6_1_19_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-2742"},{"key":"e_1_2_6_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.11.016"},{"key":"e_1_2_6_1_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40748-017-0056-y"},{"key":"e_1_2_6_1_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1514212"},{"key":"e_1_2_6_1_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X1504300113"},{"key":"e_1_2_6_1_24_1","unstructured":"DudykevychT HahnG FrerichsI HinzJ HelligeGA concept for evaluation of clinically relevant pulmonary parameters by high performance electrical impedance tomography (EIT). Paper presented at: 2nd European Medical and Biological Engineering Conference; December4\u20108 2002; Vienna Austria."},{"key":"e_1_2_6_1_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-009-1589-y"},{"key":"e_1_2_6_1_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-003-1726-y"},{"key":"e_1_2_6_1_27_1","doi-asserted-by":"publisher","DOI":"10.1159\/000193994"},{"key":"e_1_2_6_1_28_1","doi-asserted-by":"publisher","DOI":"10.1088\/0967-3334\/27\/5\/S10"},{"key":"e_1_2_6_1_29_1","doi-asserted-by":"publisher","DOI":"10.1088\/0967-3334\/27\/11\/008"},{"key":"e_1_2_6_1_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1985.58.4.1263"},{"key":"e_1_2_6_1_31_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.2000.16d28.x"},{"key":"e_1_2_6_1_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2016.05.080"},{"key":"e_1_2_6_1_33_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-0617"},{"key":"e_1_2_6_1_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001703-200104000-00009"},{"key":"e_1_2_6_1_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-013-2879-y"},{"key":"e_1_2_6_1_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-016-4663-2"},{"key":"e_1_2_6_1_37_1","doi-asserted-by":"publisher","DOI":"10.2345\/0899-8205-45.1.69"},{"key":"e_1_2_6_1_38_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-0957"},{"key":"e_1_2_6_1_39_1","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.04317"},{"key":"e_1_2_6_1_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000000011"},{"key":"e_1_2_6_1_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.23022"},{"key":"e_1_2_6_1_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.13605"},{"key":"e_1_2_6_1_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2016.02.051"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.24418","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ppul.24418","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.24418","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T22:42:24Z","timestamp":1694299344000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.24418"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,8]]},"references-count":42,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1002\/ppul.24418"],"URL":"https:\/\/doi.org\/10.1002\/ppul.24418","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,8]]},"assertion":[{"value":"2019-04-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}