{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T22:10:10Z","timestamp":1768687810809,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,7,16]],"date-time":"2019-07-16T00:00:00Z","timestamp":1563235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Canadian Inuit infants suffer the highest rate of lower respiratory tract infections (LRTI's) in the world. The causes of this are incompletely understood. The primary objective of this study was to determine whether there exists an association between respiratory morbidity and oral aspiration in Inuit children. A retrospective chart review was conducted including children from Nunavut who underwent Video Fluoroscopic Swallowing Study between the years of 2001 to 2015. The primary outcome was hospitalization for LRTI. We hypothesized that infants found to have aspiration would experience a higher rate of admissions for LRTI than those with normal swallowing studies. One\u2010hundred and twenty\u2010seven patients were identified, of whom 94 were included. Fifty\u2010six percent of patients had an abnormal swallowing study. Compared with patients with normal swallowing, the incidence rate of LRTI was higher in patients with aspiration (incidence rate ratio [IRR]\u2009=\u20091.51; 95% confidence interval [CI]\u2009=\u20091.23\u20101.87) and in patients with penetration (IRR\u2009=\u20091.40; 95% CI\u2009=\u20091.11\u20101.76). Fourteen percent of patients had confirmed laryngeal cleft; patients with confirmed presence of this also had a higher incidence rate of LRTI (IRR\u2009=\u20091.66; 95% CI\u2009=\u20091.32\u20102.07). The incidence of abnormal swallowing study showed an 11\u2010fold variation across the five regions in Nunavut, with the highest prevalence in west Qikiqtani Region (Baffin Island). We conclude that swallowing dysfunction is not only prevalent amongst Canadian Inuit but clinically significant. This is the first study to demonstrate an association between swallowing dysfunction and respiratory morbidity in this population. Geographic distribution patterns and high rates of laryngeal cleft may point to a potential genetic etiology for what remains at this point, idiopathic swallowing dysfunction.<\/jats:p>","DOI":"10.1002\/ppul.24447","type":"journal-article","created":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T06:04:51Z","timestamp":1563343491000},"page":"1837-1843","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Oral aspiration, type 1 laryngeal cleft, and respiratory tract infections in canadian inuit children"],"prefix":"10.1002","volume":"54","author":[{"given":"Sarah","family":"Farrow","sequence":"first","affiliation":[{"name":"Department of Pediatrics Stollery Children's Hospital  Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amisha","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Children's Hospital of Eastern Ontario Research Institute  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy","family":"Saban","sequence":"additional","affiliation":[{"name":"Children's Hospital of Eastern Ontario Research Institute  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darcy","family":"Scott","sequence":"additional","affiliation":[{"name":"Stanton Territorial Hospital  Yellowknife Northwest Territories Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4704-9595","authenticated-orcid":false,"given":"Nick","family":"Barrowman","sequence":"additional","affiliation":[{"name":"Children's Hospital of Eastern Ontario Research Institute  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0521-8936","authenticated-orcid":false,"given":"Thomas","family":"Kovesi","sequence":"additional","affiliation":[{"name":"Children's Hospital of Eastern Ontario Research Institute  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,7,16]]},"reference":[{"key":"e_1_2_7_1_2_1","first-page":"1847","article-title":"Lower respiratory tract infections in Inuit infants on Baffin Island","volume":"164","author":"Banerji A","year":"2001","journal-title":"CMAJ"},{"key":"e_1_2_7_1_3_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.061574"},{"key":"e_1_2_7_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20489"},{"key":"e_1_2_7_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.21489"},{"key":"e_1_2_7_1_6_1","unstructured":"DuvalM MacCormickJ KovesiT ChurcherEEtiology of Aspiration in Non\u2010Syndromic Canadian Inuit Children [abstract].Canadian Society of Otolaryngology\u2010Head and Neck Surgery 66th Annual Meeting 2012 May 20\u201022; Toronto Canada."},{"key":"e_1_2_7_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2015.08.016"},{"key":"e_1_2_7_1_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-002-0085-0"},{"key":"e_1_2_7_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_2_7_1_10_1","unstructured":"Statistics Canada.2015Aboriginal Statistics at a Glance: 2nd Edition [cited 2019 Jan 27]. 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