{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T18:16:27Z","timestamp":1758824187785,"version":"3.37.3"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,7,24]],"date-time":"2019-07-24T00:00:00Z","timestamp":1563926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study describes the effect of high\u2010frequency oscillation on airway pressure generated by high flow nasal cannula (HFNC) in a premature infant lung model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design\/Methods<\/jats:title><jats:p>A premature in 0.5 or 1.0\u2009mL\/cmH\n<jats:sub>2<\/jats:sub>O, respiratory rate (RR) of 40 or 60 breaths per min, and tidal volume of 6\u2009mL. Oscillation was achieved by passing the HFNC supply flow through a 3\u2010way solenoid valve operating at 4, 6, 8, or 10\u2009Hz. Airway pressure at the simulated trachea was recorded following equilibration of end\u2010tidal CO\n<jats:sub>2<\/jats:sub> both with and without oscillation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Superimposing high\u2010frequency oscillations onto HFNC resulted in an average decrease in mean airway pressure of 17.9% (<jats:italic>P<\/jats:italic>\u2009=\u2009.011). The difference between the maximum and minimum airway pressures, \u2206\n<jats:italic>P<\/jats:italic>\n<jats:sub>min\u2010max,<\/jats:sub> significantly increased as oscillation frequency decreased (\n<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). Airway pressure during oscillation was 12.8% greater with the 1.0 vs the 0.5\u2009mL\/cmH\n<jats:sub>2<\/jats:sub>O compliance at flows\u2009&gt;\u20094\u2009L\/min (\n<jats:italic>P<\/jats:italic>\u2009=\u2009.031). CO\n<jats:sub>2<\/jats:sub> clearance was 13.1% greater with the 1.0 vs 0.5\u2009mL\/cmH\n<jats:sub>2<\/jats:sub>O compliance at oscillation frequencies less than 8\u2009Hz (\n<jats:italic>P<\/jats:italic>\u2009=\u2009.015).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this in\u2010vitro study we demonstrate that delivered mean airway pressure decreases when applying high\u2010frequency oscillation to HFNC, while still improving CO<jats:sub>2<\/jats:sub> clearance. The combination of improved CO\n<jats:sub>2<\/jats:sub> clearance and reduced pressure delivery of this novel noninvasive modality may prove to be a useful improvement in the respiratory care of infants in respiratory distress.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.24459","type":"journal-article","created":{"date-parts":[[2019,7,24]],"date-time":"2019-07-24T07:20:04Z","timestamp":1563952804000},"page":"1860-1865","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Effect of high\u2010frequency oscillation on pressure delivered by high flow nasal cannula in a premature infant lung model"],"prefix":"10.1002","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3687-7325","authenticated-orcid":false,"given":"David M.","family":"Rub","sequence":"first","affiliation":[{"name":"Division of Neonatology Children's Hospital of Philadelphia  Philadelphia Pennsylvania"},{"name":"Department of Pediatrics, Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9756-3261","authenticated-orcid":false,"given":"Emidio M.","family":"Sivieri","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania"},{"name":"CHOP Newborn Care at Pennsylvania Hospital  Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soraya","family":"Abbasi","sequence":"additional","affiliation":[{"name":"Division of Neonatology Children's Hospital of Philadelphia  Philadelphia Pennsylvania"},{"name":"Department of Pediatrics, Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania"},{"name":"CHOP Newborn Care at Pennsylvania Hospital  Philadelphia 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