{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T13:16:54Z","timestamp":1788959814727,"version":"build-2803163510"},"reference-count":42,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T00:00:00Z","timestamp":1565222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2013\/12499\u20100"],"award-info":[{"award-number":["2013\/12499\u20100"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare rates of treatment failure between the use of nasal continuous positive airway pressure (NCPAP) and noninvasive neurally adjusted ventilatory assist (NIV\u2010NAVA) in infants with respiratory distress after birth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A randomized, unblinded, double\u2010center trial was conducted in infants with birth weights (BWs) less than or equal to 1500\u2009g and respiratory distress receiving noninvasive respiratory support for less than or equal to 48\u2009hours of life; some infants were initially treated with minimally invasive surfactant therapy as the standard of care. Primary outcome: need for endotracheal intubation with use of mechanical ventilation (MV) at less than or equal to 72\u2009hours of life using prespecified failure criteria. Secondary outcomes: use of surfactant, duration of noninvasive support, duration of MV, bronchopulmonary dysplasia (BPD) and death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 123 infants were included (NCPAP group\u2009=\u200964 and NIV\u2010NAVA group\u2009=\u200959). Population characteristics were similar between groups. No difference in the primary outcome was observed: NCPAP\u2009=\u200910 (15.6%) and NIV\u2010NAVA\u2009=\u200912 (20.3%), <jats:italic>P<\/jats:italic>\u2009=\u2009.65. Groups were also similar in the use of surfactant (19 vs 17), duration of noninvasive support (147\u2009\u00b1\u2009181\u2009hours vs 127\u2009\u00b1\u2009137\u2009hours), BPD incidence and death. However, duration of MV was significantly longer in NCPAP group (95.6\u2009\u00b1\u200945.8\u2009hours vs 28.25\u2009\u00b1\u200934.1\u2009hour), <jats:italic>P<\/jats:italic>\u2009=\u2009.01.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In infants with respiratory distress after birth, no differences in treatment failures were observed between NIV\u2010NAVA and NCPAP. These results require further evaluation in a larger study.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.24466","type":"journal-article","created":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T09:38:25Z","timestamp":1565257105000},"page":"1704-1711","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Nasal continuous positive airway pressure (NCPAP) or noninvasive neurally adjusted ventilatory assist (NIV\u2010NAVA) for preterm infants with respiratory distress after birth: A randomized controlled trial"],"prefix":"10.1002","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2985-7545","authenticated-orcid":false,"given":"Ana C.","family":"Yagui","sequence":"first","affiliation":[{"name":"Hospital Israelita Albert Einstein  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jucille","family":"Meneses","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Integral Prof. Fernandes Figueira  Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca A.","family":"Z\u00f3lio","sequence":"additional","affiliation":[{"name":"Hospital Israelita Albert Einstein  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela M. 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