{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T15:21:41Z","timestamp":1778685701934,"version":"3.51.4"},"reference-count":34,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T00:00:00Z","timestamp":1567987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Department and NTWC Training and Development Committee Fund"},{"name":"Australia's National Health and Medical Research Council Practitioner Fellowship","award":["Fellowship no:1058213"],"award-info":[{"award-number":["Fellowship no:1058213"]}]},{"name":"Children's Hospital Foundation Queensland","award":["50286"],"award-info":[{"award-number":["50286"]}]},{"name":"Children's Hospital Foundation Queensland","award":["RPC0772019"],"award-info":[{"award-number":["RPC0772019"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic wet cough is common in pediatric pulmonology practice and is clinically important. Guidelines recommend treatment with antibiotics as their effectiveness has been proven. However, factors associated with duration of cough in response to antibiotics in children with chronic wet cough have not been prospectively examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine if demographic, clinical and\/or bronchoalveolar lavage (BAL) factors are associated with \u201ctime to cough resolution\u201d in children with chronic wet cough treated with antibiotics after bronchoscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from children with chronic wet cough treated with antibiotics after bronchoscopy were extracted from a prospective cohort study database. Cough dairies were used to determine when the cough resolved. Associations between various factors with \u201ctime to cough resolution\u201d were examined using regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median age of the 133 children was 2.4 years (interquartile range, 1.4\u20104.9). Duration of prior cough at bronchoscopy was significantly positively related with \u201ctime to cough resolution\u201d (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009.010; 95% confidence interval, 0.004\u20100.017; <jats:italic>P<\/jats:italic>\u2009=\u2009.002). This translated to; for each month of prior cough, it took an extra 1.02 days to achieve cough resolution while on antibiotic treatment. Gender, age, diagnosis, tobacco smoke exposure, pneumonia history, blood cellularity, and BAL cellular and microbiology profiles were not significantly associated with time to cough resolution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In children with chronic wet cough, duration of cough before antibiotic treatment is a small but significant determinant of \u201ctime to cough resolution.\u201d Research using standardized antibiotic regimes is required to provide clinical and\/or biomarkers that can further identify factors associated with the response of chronic cough to antibiotic treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.24506","type":"journal-article","created":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T07:19:55Z","timestamp":1568013595000},"page":"1997-2002","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Predictors of time to cough resolution in children with chronic wet cough treated with antibiotics after bronchoscopy"],"prefix":"10.1002","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2689-153X","authenticated-orcid":false,"given":"Oi Yin","family":"Wong","sequence":"first","affiliation":[{"name":"Department of Paediatric and Adolescent Medicine Tuen Mun Hospital Tuen Mun Hong Kong"},{"name":"Children's Centre of Health Research Queensland University of Technology Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie M.","family":"Marchant","sequence":"additional","affiliation":[{"name":"Children's Centre of Health Research Queensland University of Technology Brisbane Queensland Australia"},{"name":"Department of Respiratory and Sleep Medicine, Children's Health Queensland Queensland Children's Hospital Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie T.","family":"Yerkovich","sequence":"additional","affiliation":[{"name":"School of Medicine The University of Queensland Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne B.","family":"Chang","sequence":"additional","affiliation":[{"name":"Children's Centre of Health Research Queensland University of Technology Brisbane Queensland Australia"},{"name":"Department of Respiratory and Sleep Medicine, Children's Health Queensland Queensland Children's Hospital Brisbane Queensland Australia"},{"name":"Child Health Division Menzies School of Health Research Darwin Northern Territory 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