{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:11:19Z","timestamp":1792642279177,"version":"4.5.0"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,9,26]],"date-time":"2019-09-26T00:00:00Z","timestamp":1569456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p><jats:italic>Pseudomonas aeruginosa<\/jats:italic> cross\u2010infections are related to increased morbidity and mortality in cystic fibrosis (CF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of the study was to evaluate the incidence of cross\u2010infections with <jats:italic>P. aeruginosa<\/jats:italic> in children with CF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>CF patients from whom at least one <jats:italic>P. aeruginosa<\/jats:italic> strain had been isolated were included in the study. The strain genotyping was performed using pulse\u2010field gel electrophoresis. The history of contacts between patients was established based on questionnaires.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study group consisted of 75 patients (aged 1.0\u201019.2 years) and the material included 170 <jats:italic>P. aeruginosa<\/jats:italic> strains. Cross\u2010infections occurred in a group of 26 patients. In this group, the risk of the predicted occurrence of forced expiratory volume in 1\u2009second\u2009\u2264\u200970% was five times greater and the risk of longer cumulative hospitalization time for intravenous antibiotic therapy (&gt;14 days\/year) was almost five times greater. In the clonal groups of strains, the multidrug\u2010resistance rate was significantly higher than in other groups. In 2011, all tested strains were susceptible to colistin, whereas in 2012, three strains from the largest clonal group showed high levels of resistance to colistin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Cross\u2010infections with <jats:italic>P. aeruginosa<\/jats:italic> occurred in our group of patients and were associated with poor clinical outcomes. Antimicrobial resistance rate in the strains isolated from such infections was significantly higher, and this included three strains resistant to colistin.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.24535","type":"journal-article","created":{"date-parts":[[2019,9,26]],"date-time":"2019-09-26T08:58:12Z","timestamp":1569488292000},"page":"161-168","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Clinical outcomes for cystic fibrosis patients with <i>Pseudomonas aeruginosa<\/i> cross\u2010infections"],"prefix":"10.1002","volume":"55","author":[{"given":"Justyna","family":"Milczewska","sequence":"first","affiliation":[{"name":"Cystic Fibrosis Department Institute of Mother and Child  Warsaw Poland"},{"name":"Cystic Fibrosis Center Children's Hospital in Dziekan\u00f3w Le\u015bny  Warsaw 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