{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:45:15Z","timestamp":1792028715270,"version":"4.4.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,12,9]],"date-time":"2019-12-09T00:00:00Z","timestamp":1575849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to investigate the status and effects of vitamin D supplement as adjuvant therapy in the management of respiratory distress syndrome (RDS) in preterm infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patient and Methods<\/jats:title><jats:p>Vitamin D was prospectively studied in 196 preterm neonates, 96 of them developed RDS, which further subdivided into three subgroups (subgroup received just conventional therapy, subgroup received conventional therapy plus vitamin D 400\u2009IU\/day, and subgroup received conventional therapy plus vitamin D 800\u2009IU\/day). The patient selection for each treatment subgroup was done by computed randomization, and all the patients had the same treatment protocols assigned for each subgroup.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The preterm group who developed RDS had lower vitamin D concentrations than the preterm group without RDS (*<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). Also, the subgroups supplemented with vitamin D had lower Downes Respiratory Distress score and PaCO<jats:sub>2<\/jats:sub> levels, less duration of hospitalization, and complications rates than the subgroup without vitamin D supplementation. The subgroup supplemented with 800\u2009IU\/day vitamin D showed also significantly improvement, less hospitalization duration, and less complications than those supplemented with 400\u2009IU\/day.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>25\u2010hydroxyvitamin D concentration was deficient in most preterm babies especially those who developed RDS. Administration of 800\u2009IU\/day vitamin D as an adjuvant therapy in cases of RDS was associated with significant decreased in severity, rate of complications, and duration of hospital stay in preterm neonates with RDS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.24552","type":"journal-article","created":{"date-parts":[[2019,12,9]],"date-time":"2019-12-09T11:35:10Z","timestamp":1575891310000},"page":"108-115","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Vitamin D status in preterm neonates and the effects of its supplementation on respiratory distress syndrome"],"prefix":"10.1002","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7761-9536","authenticated-orcid":false,"given":"Mohammed","family":"Al\u2010Beltagi","sequence":"first","affiliation":[{"name":"Pediatric Department, Faculty of Medicine Tanta University Tanta 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