{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T17:37:50Z","timestamp":1785346670362,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,11,11]],"date-time":"2019-11-11T00:00:00Z","timestamp":1573430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess changes in neonatal lung ultrasonography score (nLUS) after surfactant administration in preterm infants with respiratory distress syndrome (RDS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Working Hypothesis<\/jats:title><jats:p>The reduction of nLUS score before (nLUSpre), 2\u2009hours (nLUS2h), and 12\u2009hours (nLUS12h) after surfactant administration to identify patients who will not need a second treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Setting<\/jats:title><jats:p>Prospective observational study in the tertiary neonatal intensive care unit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients Selection<\/jats:title><jats:p>Forty\u2010six preterm neonates with RDS of 32 weeks median gestational age (IQR 30\u201033) and mean birth weight of 1650\u2009\u00b1\u2009715\u2009g.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>Lung ultrasonography was performed before, 2\u2009hours, and 12\u2009hours after surfactant administration in preterm infants with RDS needing surfactant treatment. Resulting nLUS was analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The Wilcoxon signed\u2010rank test demonstrated an nLUS lowering after 2\u2009hours (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001) and 12\u2009hours (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001) from surfactant administration. Sixteen newborns required surfactant retreatment with median gestational age of 32 weeks (IQR 29\u201033) and mean birth weight of 1519\u2009\u00b1\u2009506\u2009g.The receiver operating characteristic analysis for the nLUS2h yielded an area under the curve of 0.80 (95% confidence interval, 0.76\u20100.85; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). A nLUS2h \u22657 showed a sensitivity of 94% and a specificity of 60% for needing a second treatment with surfactant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In preterm infants with RDS requiring surfactant treatment, nLUS evaluated 2\u2009hours after surfactant administration can be used to identify patients who will not need a second treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.24566","type":"journal-article","created":{"date-parts":[[2019,11,11]],"date-time":"2019-11-11T12:59:53Z","timestamp":1573477193000},"page":"116-121","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Neonatal lung ultrasonography score after surfactant in preterm infants: A prospective observational study"],"prefix":"10.1002","volume":"55","author":[{"given":"Alessandro","family":"Perri","sequence":"first","affiliation":[{"name":"Area of Child Health, Department of Woman, Child Health and Public Health IRCCS Fondazione Policlinico Universitario Agostino Gemelli Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena","family":"Tana","sequence":"additional","affiliation":[{"name":"Area of Child Health, Department of Woman, Child Health and Public Health IRCCS Fondazione Policlinico Universitario Agostino Gemelli Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9590-7948","authenticated-orcid":false,"given":"Riccardo","family":"Riccardi","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit San Giovanni Calibita Fatebenefratelli Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossella","family":"Iannotta","sequence":"additional","affiliation":[{"name":"Area of Child Health, Department of Woman, Child Health and Public Health IRCCS Fondazione Policlinico Universitario Agostino Gemelli Rome 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Molfetta","sequence":"additional","affiliation":[{"name":"Department of Radiology IRCCS Fondazione Policlinico Universitario Agostino Gemelli Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Zecca","sequence":"additional","affiliation":[{"name":"Area of Child Health, Department of Woman, Child Health and Public Health IRCCS Fondazione Policlinico Universitario Agostino Gemelli Rome Italy"},{"name":"Universit\u00e0 Cattolica del Sacro Cuore Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3121-9569","authenticated-orcid":false,"given":"Giovanni","family":"Vento","sequence":"additional","affiliation":[{"name":"Area of Child Health, Department of Woman, Child Health and Public Health IRCCS Fondazione Policlinico Universitario Agostino Gemelli Rome Italy"},{"name":"Universit\u00e0 Cattolica del Sacro Cuore Rome 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