{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:53:28Z","timestamp":1786978408188,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,11,26]],"date-time":"2019-11-26T00:00:00Z","timestamp":1574726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Acute bronchiolitis is responsible for high morbidity in infants. Club cell protein 16\u2009kDa\u00a0(CC16) is a major pneumoprotein secreted by club cells of the bronchial epithelium and eliminated by the renal pathway. CC16 seems to be a biomarker of epithelial damage in asthma. However, its value as a marker of acute bronchiolitis severity and later recurrent wheezing are uncertain, especially the value of its urinary assay for this purpose. A prospective, observational, analytical study was conducted at Clermont\u2010Ferrand University Hospital to correlate serum CC16 level with clinical severity of bronchiolitis in hospitalized infants aged less than 1\u2009year. We analyzed correlations between serum and urinary CC16, CC16 levels and Wainwright score, immediate morbidity due to bronchiolitis, causal viruses, and recurrent wheezing 1 year after inclusion. In 166 infants, serum CC16 did not correlate with acute bronchiolitis severity (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u2009.49), but urinary CC16 did (\n                    <jats:italic>P\u2009<\/jats:italic>\n                    &lt;\u2009.001). In multivariate analysis, urinary CC16 correlated mainly with urinary retinol binding protein (RBP;\u00a0\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.70;\u00a0\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u2009.001). The logCC16u\/logRBPu ratio correlated significantly with severity (\n                    <jats:italic>P\u2009<\/jats:italic>\n                    =\u2009.02). CC16 levels were not correlated with recurrent wheezing at 1 year. Urinary CC16 could be a useful biomarker in acute bronchiolitis for specific indications. This noninvasive assay would be particularly useful in the young infant population. Several factors must be taken into account in its interpretation, mainly tubular function. Further studies are needed to assess these factors.\n                  <\/jats:p>","DOI":"10.1002\/ppul.24584","type":"journal-article","created":{"date-parts":[[2019,11,26]],"date-time":"2019-11-26T12:10:19Z","timestamp":1574770219000},"page":"490-495","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Urinary club cell protein 16 (CC16): Utility of its assay during acute bronchiolitis"],"prefix":"10.1002","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5832-3572","authenticated-orcid":false,"given":"Carole","family":"Egron","sequence":"first","affiliation":[{"name":"Department of Pediatrics CHU Clermont\u2010Ferrand Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Labb\u00e9","sequence":"additional","affiliation":[{"name":"Department of Pediatrics,\u00a0CHU Clermont\u2010Ferrand University Clermont Auvergne Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5180-9916","authenticated-orcid":false,"given":"Emmanuelle","family":"Rochette","sequence":"additional","affiliation":[{"name":"Department of Clinical Research for Children (CRECHE) at CHU Clermont\u2010Ferrand  Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lien","family":"Mulliez","sequence":"additional","affiliation":[{"name":"Department of Clinical Research and Innovation at CHU Clermont\u2010Ferrand Hospital Engineer Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3171-3743","authenticated-orcid":false,"given":"Alfred","family":"Bernard","sequence":"additional","affiliation":[{"name":"Louvain Center of Toxicology and Applied Pharmacology Catholic University of Louvain Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7843-7999","authenticated-orcid":false,"given":"Flore","family":"Amat","sequence":"additional","affiliation":[{"name":"Center of Asthma and Allergy, AP\u2010HP, Groupe hospitalier Trousseau\u2010La Roche Guyon Pierre and Marie Curie University Paris 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