{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T12:26:25Z","timestamp":1765974385662,"version":"3.37.3"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,12,17]],"date-time":"2019-12-17T00:00:00Z","timestamp":1576540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"University Malaya Research Grant","award":["UMRG-RP026-14HTM"],"award-info":[{"award-number":["UMRG-RP026-14HTM"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Respiratory tract infections in children can result in respiratory sequelae. We aimed to determine the prevalence of, and factors associated with persistent respiratory sequelae 1 year after admission for a lower respiratory tract infection (LRTI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>This prospective cohort study involved children 1 month to 5\u2010years\u2010old admitted with an LRTI. Children with asthma were excluded. Patients were reviewed at 1\u2010, 6\u2010, and 12\u2010months post\u2010hospital discharge. The parent cough\u2010specific quality of life, the depression, anxiety, and stress scale questionnaire and cough diary for 1 month, were administered. Outcomes reviewed were number of unscheduled healthcare visits, respiratory symptoms and final respiratory diagnosis at 6 and\/or 12 month\u2010review by pediatric pulmonologists.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three hundred patients with a mean\u2009\u00b1\u2009SD age of 14\u2009\u00b1\u200915 months old were recruited. After 1 month, 239 (79.7%) returned: 28.5% (n\u2009=\u200968\/239) had sought medical advice and 18% (n\u2009=\u200943\/239) had\u00a0cough at clinic review. Children who received antibiotics in hospital had significantly lower total cough scores (<jats:italic>P<\/jats:italic>\u2009=\u2009.005) as per the cough diary. After 1 year, 26% (n\u2009=\u200978\/300) had a respiratory problem, predominantly preschool wheezing phenotype (n\u2009=\u200964\/78, 82.1%). Three children had bronchiectasis or bronchiolitis obliterans. The parent cough\u2010specific quality of life (PCQOL) was significantly lower in children with respiratory sequelae (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01). In logistic regression, the use of antibiotics in hospitals (adjusted odds ratio, 0.46; <jats:italic>P<\/jats:italic>\u2009=\u2009.005) was associated with reduced risk of respiratory sequelae.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In children admitted for LRTI, a quarter had respiratory sequelae, of which preschool wheeze was the commonest. The use of antibiotics was associated with a lower risk of respiratory sequelae.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.24598","type":"journal-article","created":{"date-parts":[[2019,12,17]],"date-time":"2019-12-17T15:13:11Z","timestamp":1576595591000},"page":"407-417","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Respiratory sequelae and quality of life in children one\u2010year after being admitted with a lower respiratory tract infection: A prospective cohort study from a developing country"],"prefix":"10.1002","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3618-5820","authenticated-orcid":false,"given":"Anna M.","family":"Nathan","sequence":"first","affiliation":[{"name":"Department of Paediatrics University Malaya  Kuala Lumpur Malaysia"},{"name":"Child Health Research Group University Malaya  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cindy S.J.","family":"Teh","sequence":"additional","affiliation":[{"name":"Department of Microbiology University Malaya  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kah Peng","family":"Eg","sequence":"additional","affiliation":[{"name":"Department of Paediatrics University Malaya  Kuala Lumpur Malaysia"},{"name":"Child Health Research Group University Malaya  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kartini A.","family":"Jabar","sequence":"additional","affiliation":[{"name":"Department of Microbiology University Malaya  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafdzah","family":"Zaki","sequence":"additional","affiliation":[{"name":"Department of Social &amp; Preventive Medicine Centre for Epidemiology and Evidence\u2010Based Practice  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shih Ying","family":"Hng","sequence":"additional","affiliation":[{"name":"Department of Paediatrics University Malaya  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Westerhout","sequence":"additional","affiliation":[{"name":"Department of Biomedical Imaging University Malaya Medical Centre  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4414-7915","authenticated-orcid":false,"given":"Surendran","family":"Thavagnanam","sequence":"additional","affiliation":[{"name":"Department of Paediatrics University Malaya  Kuala Lumpur Malaysia"},{"name":"Child Health Research Group University Malaya  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessie A.","family":"de Bruyne","sequence":"additional","affiliation":[{"name":"Department of Paediatrics University Malaya  Kuala Lumpur Malaysia"},{"name":"Child Health Research Group University Malaya  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,12,17]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/fampra\/cmg613"},{"key":"e_1_2_5_3_1","first-page":"401","article-title":"The natural history of acute cough in children aged 0 to 4 years in primary care: a systematic review","volume":"52","author":"Hay AD","year":"2002","journal-title":"Br J Gen Pract"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-2236"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.22661"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2007.128900"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2010.tb03949.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.10289"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197303082881005"},{"key":"e_1_2_5_10_1","first-page":"527","article-title":"Long\u2010term morbidity from severe pneumonia in early childhood in the Gambia, West Africa: a follow\u2010up study","volume":"13","author":"Puchalski Ritchie LM","year":"2009","journal-title":"Int J Tuberc Lung Dis"},{"key":"e_1_2_5_11_1","first-page":"325","article-title":"A retrospective study of children after pneumonia","volume":"66","author":"Wesley AG","year":"1984","journal-title":"S Afr Med J"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031239"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.10.004"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.23001"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1348\/014466503321903544"},{"key":"e_1_2_5_16_1","first-page":"82","article-title":"Translation, validation, and psychometric properties of Bahasa Malaysia version of the depression anxiety and stress scales (DASS)","volume":"8","author":"Musa R","year":"2007","journal-title":"ASEAN Journal of Psychiatry"},{"key":"e_1_2_5_17_1","unstructured":"CDC growth charts 2009. 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