{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T12:46:35Z","timestamp":1763642795414,"version":"3.37.3"},"reference-count":45,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2020,1,28]],"date-time":"2020-01-28T00:00:00Z","timestamp":1580169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"WG Teague receives salary support from the Ivy Foundation, University of Virginia, and a grant-in-aid from the American Lung Association Airways Clinical Research Centers."}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Purpose<\/jats:title><jats:p>Asthmatics with severe exercise\u2010induced bronchoconstriction (EIB) are at high risk of exacerbations. The purpose of this study was to determine the prevalence, phenotypic, and laboratory determinants of severe EIB in Nigerian children with asthma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Children with controlled asthma (n\u2009=\u2009101) underwent characterization and free\u2010running exercise bronchoprovocation at a center in Nigeria. Lung function was measured before, then 5, 10, 15, and 30\u2009minutes after 6 to 8\u2009minutes exercise. Severe EIB was defined as \u226550% decrease in forced expired volume in 1 second (FEV<jats:sub>1<\/jats:sub>) from preexercise. Serum vitamin D and total antioxidant capacity were measured chromatographically. Factors predicting severe EIB were tested by logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>The sample was enriched in children with corticosteroid\u2010na\u00efve, mild intermittent asthma (71%). Thirteen percent had no EIB, 22% had severe and 65% nonsevere EIB. Children with severe EIB had higher preexercise FVC (105% vs 96%; <jats:italic>P<\/jats:italic>\u2009=\u2009.03) and FEV<jats:sub>1<\/jats:sub> (98% vs 90%; <jats:italic>P<\/jats:italic>\u2009=\u2009.07), greater obesity (13.6% vs 1.3%; <jats:italic>P<\/jats:italic>\u2009=\u2009.02), more allergic rhinitis (AR) (63.6% vs 35.4%; <jats:italic>P<\/jats:italic>\u2009=\u2009.03), but less exposure to household pets (31.8% vs 72.2%; <jats:italic>P<\/jats:italic>\u2009=\u2009.003) compared to children with nonsevere EIB. Significant determinants (odds ratios\/confidence intervals) for severe EIB were obesity\u2009=\u200912.3 (1.2\u2010125.1), AR\u2009=\u20093.18 (1.19\u20108.52), blood eosinophilia\u2009=\u20091.005 (1.001\u20101.009), and hypovitaminosis D\u2009=\u20090.87 (0.81\u20100.93).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In Nigerian children with asthma, severe EIB is common and associated with remediable comorbidities including type 2 pattern inflammation and vitamin D deficiency.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.24609","type":"journal-article","created":{"date-parts":[[2020,1,28]],"date-time":"2020-01-28T12:57:54Z","timestamp":1580216274000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Determinants of severe exercise\u2010induced bronchoconstriction in Nigerian children with asthma"],"prefix":"10.1002","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4778-4362","authenticated-orcid":false,"given":"Bankole Peter","family":"Kuti","sequence":"first","affiliation":[{"name":"Department of Paediatrics Wesley Guild Hospital  Ilesa Nigeria"},{"name":"Department of Paediatrics and Child Health Obafemi Awolowo University  Ile\u2010Ife Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Demilade Kehinde","family":"Kuti","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Wesley Guild Hospital  Ilesa Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Williams G.","family":"Teague","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Allergy, Immunology, and Sleep, Department of Pediatrics, Child Health Research Center University of Virginia School of Medicine  Charlottesville Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,1,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201303-0437ST"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.98.12040879"},{"key":"e_1_2_8_4_1","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1183\/09031936.95.08050729","article-title":"An exercise challenge for epidemiological studies of childhood asthma: validity and repeatability","volume":"8","author":"Haby MM","year":"1995","journal-title":"Eur Respir J"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41533-018-0098-2"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2016.00016"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.126.2.528"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.08-OA-0034"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.04.035"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-200205001-00866"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2000.00748.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.17"},{"key":"e_1_2_8_13_1","unstructured":"Nigerian Nutrition and health survey 2015. 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