{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T17:54:24Z","timestamp":1790445264095,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T00:00:00Z","timestamp":1581984000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Australian National Health and Medical Research Council (NHMRC) Practitioner Fellowship","award":["APP1058213"],"award-info":[{"award-number":["APP1058213"]}]},{"name":"Queensland Children's Hospital Foundation","award":["50286"],"award-info":[{"award-number":["50286"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>Children with bronchiectasis have recurrent exacerbations and may require hospitalization. \u201cHospital in the home (HITH)\u201d is used as an alternative to hospitalization for children with cystic fibrosis (CF) but to date, there is no published data on children without CF. We describe our experience of HITH (intravenous [IV] antibiotics and at least once\u2010daily physiotherapy\u2010treated airway clearance therapy) in a cohort of children with bronchiectasis, comparing outcomes between hospital and HITH\u2010based pathways.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Medical records were retrospectively reviewed in children with bronchiectasis who were hospitalized in our center from July 2016 to July 2018. We compared treatment duration, symptom resolution, adverse events, oral antibiotic prescription on discharge and \u201ctime\u2010to\u2010next hospitalization\u201d between children managed with the two treatment pathways.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Exacerbations in 63 children (median age\u2009=\u20096 years [range: 1\u201017]; females\u2009=\u200933, indigenous\u2009=\u20098) with bronchiectasis treated with IV antibiotic therapy were analyzed (HITH n\u2009=\u200945, 71.5%). Duration of treatment and symptom resolution was similar between groups (hospital: median\u2009=\u200914 days [interquartile range {IQR}: 14\u201014] and 12\/18 [66.6%], respectively vs HITH: 14 [14\u201015.5] and 31\/45 [69%]; <jats:italic>P<\/jats:italic>\u2009=\u2009.53 and .85, respectively). There was no significant difference in adverse events (16.6% vs 9%), prescription of oral antibiotics on discharge (44% vs 24%), or \u201ctime\u2010to\u2010next hospitalization\u201d (median 42 [IQR: 24\u2010100] vs 67 [IQR: 32\u201095] weeks) between hospital and HITH groups, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In children with bronchiectasis treated for a severe exacerbation, receiving treatment in the home setting with HITH does not compromise short\u2010term clinical outcomes compared to hospital only treatment. Prospective studies are required to provide more robust evidence in this under\u2010researched area.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.24670","type":"journal-article","created":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T13:49:00Z","timestamp":1582033740000},"page":"994-999","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Is out\u2010patient based treatment of bronchiectasis exacerbations in children comparable to inpatient based treatment?"],"prefix":"10.1002","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7321-3459","authenticated-orcid":false,"given":"Claudia","family":"O'Rourke","sequence":"first","affiliation":[{"name":"Department of Respiratory &amp; Sleep Medicine Queensland Children's Hospital Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Schilling","sequence":"additional","affiliation":[{"name":"Department of Respiratory &amp; Sleep Medicine Queensland Children's Hospital Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Respiratory &amp; Sleep Medicine Queensland Children's Hospital Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Joyce","sequence":"additional","affiliation":[{"name":"Department of Paediatric Medicine, School of Medicine University of Queensland Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Bernadette Chang","sequence":"additional","affiliation":[{"name":"Department of Respiratory &amp; Sleep Medicine Queensland Children's Hospital Queensland Australia"},{"name":"Child Health Division, Menzies School of Health Research Charles Darwin University Darwin Northern Territory Australia"},{"name":"Department of Paediatrics, Children's Centre of Health Research Queensland University of Technology Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitin","family":"Kapur","sequence":"additional","affiliation":[{"name":"Department of Respiratory &amp; Sleep Medicine Queensland Children's Hospital Queensland Australia"},{"name":"Department of Paediatric Medicine, School of Medicine University of Queensland Queensland Australia"},{"name":"Department of Paediatrics, Children's Centre of Health Research Queensland University of Technology Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31554-X"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.23380"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.13296"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-0679"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(19)30254-1"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.21518"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2009.05.007"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30345-6"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201203-0487OC"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcs173"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000501085"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1569-1993(15)30444-6"},{"key":"e_1_2_7_14_1","first-page":"1917","article-title":"Home versus hospital intravenous antibiotic therapy for cystic fibrosis","volume":"12","author":"Balaguer A","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0496(199707)24:1<42::AID-PPUL7>3.0.CO;2-L"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20433"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2008.08.017"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/npjpcrm.2014.90"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(87)80337-2"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1992.tb12239.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2005.08.003"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2006.060913"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-2932"},{"key":"e_1_2_7_24_1","first-page":"66","article-title":"Recent advances in cross\u2010infection in cystic fibrosis: burkholderia cepacia complex, Pseudomonas aeruginosa, MRSA and Pandoraea spp","volume":"96","author":"Jones AM","year":"2003","journal-title":"J R Soc Med"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja14.00287"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2018-212463"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.24670","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.24670","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ppul.24670","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.24670","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T12:50:15Z","timestamp":1693572615000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.24670"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,18]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1002\/ppul.24670"],"URL":"https:\/\/doi.org\/10.1002\/ppul.24670","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,18]]},"assertion":[{"value":"2019-10-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}