{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T23:42:17Z","timestamp":1788824537771,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T00:00:00Z","timestamp":1581292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006483","name":"AbbVie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Respiratory syncytial virus infection in early childhood has been linked to longer\u2010term respiratory morbidity; however, debate persists around its impact on asthma. The objective was to assess the association between respiratory syncytial virus hospitalization and childhood asthma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Asthma hospital admissions and medication use through 18 years were compared in children with (cases) and without (controls) respiratory syncytial virus hospitalization in the first 2 years of life. All children born in National Health Service Scotland between 1996 and 2011 were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 740\u2009418 children (median follow\u2010up: 10.6 years), 15\u2009795 (2.1%) had a respiratory syncytial virus hospitalization at \u22642 years (median age: 143 days). Asthma hospitalizations were three\u2010fold higher in cases than controls (8.4% vs 2.4%; relative risk: 3.3, 95% confidence interval [CI]: 3.1\u20103.5; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001) and admission rates were four\u2010fold higher (193.2 vs 46.0\/1000). Cases had two\u2010fold higher asthma medication usage (25.5% vs 14.7%; relative risk: 1.7, 95% CI: 1.7\u20101.8; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001) and a three\u2010fold higher rate of having both an asthma admission and medication (4.8% vs 1.5%; relative risk 3.1, 95% CI: 2.9\u20103.3; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001). Admission rates and medication use remained significantly (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001) higher for cases than controls throughout childhood (admissions: \u22652\u2010fold higher; medication: \u22651.5\u2010fold higher). Respiratory syncytial virus hospitalization was the most significant risk factor for asthma hospitalizations\u00b1medication use (odds ratio: 1.9\u20102.8; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Respiratory syncytial virus hospitalization was associated with significantly increased rates and severity of asthma throughout childhood, which has important implications for preventive strategies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.24676","type":"journal-article","created":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T18:33:34Z","timestamp":1581359614000},"page":"1104-1110","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["Association between respiratory syncytial virus hospitalization in infancy and childhood asthma"],"prefix":"10.1002","volume":"55","author":[{"given":"Jonathan","family":"Coutts","sequence":"first","affiliation":[{"name":"Neonatal Unit Royal Hospital for Children Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Fullarton","sequence":"additional","affiliation":[{"name":"Health Economics &amp; Outcomes Research Strategen Limited Basingstoke UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole","family":"Morris","sequence":"additional","affiliation":[{"name":"Information Services Division Scotland Farr Institute Scotland Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ElizaBeth","family":"Grubb","sequence":"additional","affiliation":[{"name":"Health Economics &amp; Outcomes Research AbbVie Inc North Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scot","family":"Buchan","sequence":"additional","affiliation":[{"name":"Health Economics &amp; Outcomes Research Strategen Limited Basingstoke UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry","family":"Rodgers\u2010Gray","sequence":"additional","affiliation":[{"name":"Health Economics &amp; Outcomes Research Strategen Limited Basingstoke UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Thwaites","sequence":"additional","affiliation":[{"name":"Portsmouth Hospitals NHS Trust Queen Alexandra Hospital Portsmouth UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30938-8"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40121-017-0151-4"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0125422"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)10321-5"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(18)30055-9"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2009.121582"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2015-308723"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2005.00298.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200406-730OC"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20058"},{"key":"e_1_2_8_12_1","unstructured":"Global Initiative for Asthma.Global Strategy for Asthma Management and Prevention 2018.https:\/\/ginasthma.org\/2018\u2010gina\u2010report\u2010global\u2010strategy\u2010for\u2010asthma\u2010management\u2010and\u2010prevention\/. 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