{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T19:10:08Z","timestamp":1776712208014,"version":"3.51.2"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,3,2]],"date-time":"2020-03-02T00:00:00Z","timestamp":1583107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chest computed tomography (CT) in children with cystic fibrosis (CF) is sensitive in detecting early airways disease. The pressure\u2010controlled CT\u2010protocol combines a total lung capacity scan (TLC PC\u2010CT) with a near functional residual capacity scan (FRC PC\u2010CT) under general anesthesia, while another CT\u2010protocol is acquired during free breathing (FB\u2010CT) near functional residual capacity. The aim of this study was to evaluate the sensitivity in detecting airways disease of both protocols in two cohorts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Routine PC\u2010CTs (Princess Margaret Children's Hospital) and FB\u2010CTs (Erasmus MC\u2014Sophia Children's Hospital) were retrospectively collected from CF children aged 2 to 6 years. Total airways disease (%disease), bronchiectasis (%Bx), and low attenuation regions (%LAR) were scored on CTs using the Perth\u2010Rotterdam annotated grid morphometric analysis\u2010CF method. The Wilcoxon signed\u2010rank test was used for differences between TLC and FRC PC\u2010CTs and the Wilcoxon rank\u2010sum test for differences between FRC PC\u2010CTs and FB\u2010CTs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty patients with PC\u2010CTs (21 male, aged 2.5\u20105.5 years) and 42 patients with FB\u2010CTs (26 male, aged 2.3\u20106.8 years) were included. %Disease was higher on TLC PC\u2010CTs compared with FRC PC\u2010CTs (median 4.51 vs 2.49; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). %Disease and %Bx were not significantly different between TLC PC\u2010CTs and FB\u2010CTs (median 4.51% vs 3.75%; <jats:italic>P<\/jats:italic>\u2009=\u2009.143 and 0.52% vs 0.57%; <jats:italic>P<\/jats:italic>\u2009=\u2009.849). %Disease, %Bx, and %LAR were not significantly different between FRC PC\u2010CTs and FB\u2010CTs (median 2.49% vs 3.75%; <jats:italic>P<\/jats:italic>\u2009=\u2009.055, 0.54% vs 0.57%; <jats:italic>P<\/jats:italic>\u2009=\u2009.797, and 2.49% vs 1.53%; <jats:italic>P<\/jats:italic>\u2009=\u2009.448).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our data suggest that FRC PC\u2010CTs are less sensitive than TLC PC\u2010CTs and that FB\u2010CTs have similar sensitivity to PC\u2010CTs in detecting lung disease. FB\u2010CTs seem to be a viable alternative for PC\u2010CTs to track CF lung disease in young patients with CF.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.24702","type":"journal-article","created":{"date-parts":[[2020,3,2]],"date-time":"2020-03-02T16:17:04Z","timestamp":1583165824000},"page":"1161-1168","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Assessment of early lung disease in young children with CF: A comparison between pressure\u2010controlled and free\u2010breathing chest computed tomography"],"prefix":"10.1002","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3602-3883","authenticated-orcid":false,"given":"Merel C. J.","family":"Oudraad","sequence":"first","affiliation":[{"name":"Faculty of Medicine University of Utrecht Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8846-3517","authenticated-orcid":false,"given":"Wieying","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology and Allergology Erasmus MC\u2010Sophia Children's Hospital Rotterdam The Netherlands"},{"name":"Department of Radiology and Nuclear Medicine Erasmus MC Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3727-5131","authenticated-orcid":false,"given":"Tim","family":"Rosenow","sequence":"additional","affiliation":[{"name":"School of Paediatrics and Child Health The University of Western Australia Perth Australia"},{"name":"Telethon Kids Institute The University of Western Australia Perth Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5372-4163","authenticated-orcid":false,"given":"Eleni\u2010Rosalina","family":"Andrinopoulou","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Erasmus MC Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen M.","family":"Stick","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Sleep Medicine Princess Margaret Hospital for Children Perth Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harm A. 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