{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T01:20:41Z","timestamp":1771982441270,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T00:00:00Z","timestamp":1584316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Children's Hospital Foundation Queensland","award":["5006"],"award-info":[{"award-number":["5006"]}]},{"name":"Australian National Health and Medical Research Council","award":["GNT 615700"],"award-info":[{"award-number":["GNT 615700"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Respiratory syncytial virus (RSV) is an important cause of early life acute respiratory infections. Potentially pathogenic respiratory bacteria, including <jats:italic>Streptococcus pneumoniae<\/jats:italic>, <jats:italic>Moraxella catarrhalis<\/jats:italic>, and <jats:italic>Haemophilus influenzae<\/jats:italic> are frequently detected during RSV infections and associated with increased illness severity. However, the temporal dynamics of bacterial colonization associated with RSV infection remain unclear. We used weekly nasal swab data from a prospective longitudinal birth cohort in Brisbane, Australia, to investigate bacterial colonization patterns within children aged less than 2 years in the 4\u2010week period before and after an RSV infection. During 54 RSV infection episodes recorded in 47 children, both <jats:italic>S. pneumoniae<\/jats:italic> and <jats:italic>M. catarrhalis<\/jats:italic> were detected frequently (in 33 [61.1%] and 26 [48.1%] RSV infections, respectively). In most cases, <jats:italic>S. pneumoniae<\/jats:italic> and <jats:italic>M. catarrhalis<\/jats:italic> colonization preceded the viral infection, with the nasal load of each increasing during RSV infection. Generally, the dominant serotype of <jats:italic>S. pneumoniae<\/jats:italic> remained consistent in the 1 to 2 weeks immediately before and after RSV infection. Little evidence was found to indicate that prior colonization with either bacteria predisposed participants to developing RSV infection during the annual seasonal epidemic. Possible coacquisition events, where the bacteria species was first detected with RSV and not in the preceding 4 weeks, were observed in approximately 20% of RSV\/<jats:italic>S. pneumoniae<\/jats:italic> and RSV\/<jats:italic>M. catarrhalis<\/jats:italic> codetections. Taken together our results indicate that RSV generally triggered an outgrowth, rather than a new acquisition, of <jats:italic>S. pneumoniae<\/jats:italic> and <jats:italic>M. catarrhalis<\/jats:italic> from the resident microbial community.<\/jats:p>","DOI":"10.1002\/ppul.24715","type":"journal-article","created":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T16:03:54Z","timestamp":1584374634000},"page":"1237-1245","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Bacterial colonization dynamics associated with respiratory syncytial virus during early childhood"],"prefix":"10.1002","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7068-2017","authenticated-orcid":false,"given":"Jaelle C.","family":"Brealey","sequence":"first","affiliation":[{"name":"School of Chemistry and Molecular Biosciences The University of Queensland  St Lucia Queensland 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