{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:08:04Z","timestamp":1790788084222,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T00:00:00Z","timestamp":1587340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>We aimed to measure lung mechanics at birth by the forced oscillation technique (FOT) for assessment of the initial degree of lung aeration and the short\u2010term aeration changes after applying different respiratory support strategies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eighteen preterm infants (gestational age\u2009=\u200929\u201036 week) were randomized to receive either continuous positive airway pressure (CPAP) at 5\u2009cmH<jats:sub>2<\/jats:sub>O only or combined with a sustained inflation (SI; 15\u2009seconds at 25\u2009cmH<jats:sub>2<\/jats:sub>O after 5\u2009seconds of CPAP) at birth. We assessed the respiratory system reactance at 5\u2009Hz (X<jats:sub>5;<\/jats:sub> increases with lung volume recruitment at a given distending pressure) at 2, 40, and 150\u2009seconds after initiation of CPAP. k\u2010Means clustering of the initial X<jats:sub>5<\/jats:sub> value (X<jats:sub>5,i<\/jats:sub>) stratified newborn into either infants with lower (lowerX<jats:sub>5,i<\/jats:sub>; X<jats:sub>5<\/jats:sub>\u2009&lt;\u2009\u2212280\u2009cmH<jats:sub>2<\/jats:sub>O*s\/L) and higher (higherX<jats:sub>5,i<\/jats:sub>; X<jats:sub>5<\/jats:sub>\u2009&gt;\u2009\u2212240\u2009cmH<jats:sub>2<\/jats:sub>O*s\/L) initial degree of lung volume recruitment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Initial values were highly heterogeneous. In the LowerX<jats:sub>5,i<\/jats:sub> group, X<jats:sub>5<\/jats:sub> increased with time, with SI\u2010patients showing significantly higher values at 150\u2009seconds than the non\u2010SI group (X<jats:sub>5<\/jats:sub>\u2009=\u2009\u221289\u2009\u00b1\u200927\u2009cmH<jats:sub>2<\/jats:sub>O vs \u2212274\u2009\u00b1\u200958\u2009cmH<jats:sub>2<\/jats:sub>O). In the higherX<jats:sub>5,i<\/jats:sub> group, X<jats:sub>5<\/jats:sub> did not improve with time, regardless of the respiratory strategy, suggesting a lack of lung recruitment. Moreover, 75% of infants receiving SI in the higherX<jats:sub>5,i<\/jats:sub> group experienced a transient loss of aeration after the maneuver.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Preterm newborns present initially with highly heterogeneous lung aeration at birth that significantly impacts the effectiveness of the subsequent lung volume recruitment strategy. FOT may represent a valuable tool for individualizing a respiratory resuscitation at birth as it is noninvasive and may be applied simultaneously to respiratory support.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.24772","type":"journal-article","created":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T21:20:18Z","timestamp":1587417618000},"page":"1640-1645","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Changes in respiratory mechanics at birth in preterm infants: A pilot study"],"prefix":"10.1002","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8607-1728","authenticated-orcid":false,"given":"Chiara","family":"Veneroni","sequence":"first","affiliation":[{"name":"TechRes lab, Department of Electronics, Information and bioengineering Politecnico di Milano University  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenica","family":"Mercadante","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit (NICU), Fondazione IRCCS Ca'Granda Foundation Ospedale Maggiore Policlinico Hospital\u2010Universit\u00e0 degli Studi di Milano  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Lavizzari","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit (NICU), Fondazione IRCCS Ca'Granda Foundation Ospedale Maggiore Policlinico Hospital\u2010Universit\u00e0 degli Studi di Milano  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariarosa","family":"Colnaghi","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit (NICU), Fondazione IRCCS Ca'Granda Foundation Ospedale Maggiore Policlinico Hospital\u2010Universit\u00e0 degli Studi di Milano  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Mosca","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit (NICU), Fondazione IRCCS Ca'Granda Foundation Ospedale Maggiore Policlinico Hospital\u2010Universit\u00e0 degli Studi di Milano  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3672-4591","authenticated-orcid":false,"given":"Raffaele L.","family":"Dellac\u00e0","sequence":"additional","affiliation":[{"name":"TechRes lab, Department of Electronics, Information and bioengineering Politecnico di Milano University  Milano 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