{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T02:44:55Z","timestamp":1790304295130,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T00:00:00Z","timestamp":1588032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Vallecular cyst coexisting with laryngomalacia (VC\u2010LM) can cause significant pharyngolaryngeal obstruction. Traditionally, it is diagnosed with flexible endoscopy (FE) and treated by rigid endoscopy. This study evaluates the effectiveness of solely using FE with novel noninvasive ventilation (NIV) of sustained pharyngeal inflation (SPI) support for both diagnosis and treatment in such infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective review of consecutive infants who were diagnosed and treated for VC\u2010LM in the 12\u2010year period, 2007 to 2018, was conducted. Clinical variables, techniques, and outcomes were analyzed and reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighteen infants (10 males) were included. The mean age was 3.0\u2009\u00b1\u20090.6 months and the mean body weight was 4.6\u2009\u00b1\u20091.3\u2009kg. Before FE, 14 infants were supported with bi\u2010nasal prongs NIV (BN\u2010NIV) and four infants with tracheal intubation. During diagnostic and therapeutic FE, all infants supported with a nasopharyngeal NIV (NP\u2010NIV) only. All diagnoses were made in the first FE inspection of 3.5\u2009\u00b1\u20091.2\u2009minutes. Thirteen lesions were immediately treated with FE laser therapy in 18.1\u2009\u00b1\u20091.7\u2009minutes in the same FE course. Total FE time was 24.6\u2009\u00b1\u20092.8\u2009minutes. Three infants needed revision laser therapy 4 days later. There was no desaturation (&lt;90%), bradycardia (&lt;100\/min), or pneumothorax. After FE therapy, all infants were supported with BN\u2010NIV only with significantly (&lt;0.01) lower pressure and completely weaned off before being discharged 8.4\u2009\u00b1\u20091.5 days later. All infants, followed up for a 6\u2010month period, showed many clinical improvements.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>FE, with this NP\u2010NIV and SPI supports, could offer accurate diagnosis and successful laser therapy of the VC\u2010LM with procedural sedation in the same session in infants.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.24796","type":"journal-article","created":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T10:56:56Z","timestamp":1588071416000},"page":"1750-1756","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Vallecular cyst with coexisting laryngomalacia: Successful diagnosis and laser therapy by flexible endoscopy with a novel noninvasive ventilation support in infants"],"prefix":"10.1002","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8397-4956","authenticated-orcid":false,"given":"Wen\u2010Jue","family":"Soong","sequence":"first","affiliation":[{"name":"Division of Pediatric Pulmonology, China Medical University Children's Hospital China Medical University  Taichung Taiwan"},{"name":"Department of Pediatrics, School of Medicine National Yang\u2010Ming University  Taipei Taiwan"},{"name":"Department of Pediatrics Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"Department of Pediatrics Tri\u2010Service General Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia\u2010Feng","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine National Yang\u2010Ming University  Taipei Taiwan"},{"name":"Department of Pediatrics Taipei Veterans General Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Sheng","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine National Yang\u2010Ming University  Taipei Taiwan"},{"name":"Department of Pediatrics Taipei Veterans General Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei\u2010Jeng","family":"Tsao","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine National Yang\u2010Ming University  Taipei Taiwan"},{"name":"Department of Pediatrics Taipei Veterans General Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien\u2010Heng","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Pediatric Pulmonology, China Medical University Children's Hospital China Medical University  Taichung 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